Assay Detail
Binding
CHEMBL948464
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Inhibition of human recombinant AChE by Ellman's assay
20
Total Activities
20
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Structure-activity relationships of acetylcholinesterase noncovalent inhibitors based on a polyamine backbone. 4. Further investigation on the inner spacer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 7.16 | 9.43 |
| Activity | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL450553 | — | — | 1 | 9.43 |
| CHEMBL452339 | — | — | 1 | 8.85 |
| CHEMBL254016 | — | — | 1 | 8.48 |
| CHEMBL507885 | — | — | 1 | 8.32 |
| CHEMBL507903 | — | — | 1 | 8.11 |
| CHEMBL507304 | — | — | 1 | 7.85 |
| CHEMBL449467 | — | — | 1 | 7.80 |
| CHEMBL173309 | — | — | 1 | 7.79 |
| CHEMBL502 | DONEPEZIL | 4.0 | 1 | 7.64 |
| CHEMBL502877 | — | — | 1 | 7.59 |
| CHEMBL488590 | — | — | 1 | 7.27 |
| CHEMBL450990 | — | — | 1 | 7.16 |
| CHEMBL449941 | — | — | 1 | 7.14 |
| CHEMBL11805 | CAPROCTAMINE | — | 1 | 6.77 |
| CHEMBL659 | GALANTAMINE | 4.0 | 1 | 5.70 |
| CHEMBL499825 | — | — | 1 | 5.38 |
| CHEMBL450506 | — | — | 1 | 5.26 |
| CHEMBL499722 | — | — | 1 | 5.07 |
| CHEMBL345124 | PROPIDIUM | — | 1 | 4.49 |
| CHEMBL429694 | CONGO RED | -1.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL450553 | — | IC50 | = | 0.37 | nM | 9.43 |
| CHEMBL452339 | — | IC50 | = | 1.41 | nM | 8.85 |
| CHEMBL254016 | — | IC50 | = | 3.32 | nM | 8.48 |
| CHEMBL507885 | — | IC50 | = | 4.83 | nM | 8.32 |
| CHEMBL507903 | — | IC50 | = | 7.7 | nM | 8.11 |
| CHEMBL507304 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL449467 | — | IC50 | = | 15.9 | nM | 7.80 |
| CHEMBL173309 | — | IC50 | = | 16.1 | nM | 7.79 |
| CHEMBL502 | DONEPEZIL | IC50 | = | 23.1 | nM | 7.64 |
| CHEMBL502877 | — | IC50 | = | 25.7 | nM | 7.59 |
| CHEMBL488590 | — | IC50 | = | 53.5 | nM | 7.27 |
| CHEMBL450990 | — | IC50 | = | 68.9 | nM | 7.16 |
| CHEMBL449941 | — | IC50 | = | 72.4 | nM | 7.14 |
| CHEMBL11805 | CAPROCTAMINE | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL659 | GALANTAMINE | IC50 | = | 2010.0 | nM | 5.70 |
| CHEMBL499825 | — | IC50 | = | 4160.0 | nM | 5.38 |
| CHEMBL450506 | — | IC50 | = | 5470.0 | nM | 5.26 |
| CHEMBL499722 | — | IC50 | = | 8550.0 | nM | 5.07 |
| CHEMBL345124 | PROPIDIUM | IC50 | = | 32300.0 | nM | 4.49 |
| CHEMBL429694 | CONGO RED | Activity | - | — | - |