Assay Detail
Binding
CHEMBL948465
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human serum BChE by Ellman's assay
20
Total Activities
20
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Structure-activity relationships of acetylcholinesterase noncovalent inhibitors based on a polyamine backbone. 4. Further investigation on the inner spacer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 5.41 | 7.02 |
| Activity | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL452339 | — | — | 1 | 7.02 |
| CHEMBL507304 | — | — | 1 | 6.53 |
| CHEMBL488590 | — | — | 1 | 6.38 |
| CHEMBL449941 | — | — | 1 | 6.06 |
| CHEMBL507885 | — | — | 1 | 5.98 |
| CHEMBL450553 | — | — | 1 | 5.72 |
| CHEMBL449467 | — | — | 1 | 5.68 |
| CHEMBL173309 | — | — | 1 | 5.65 |
| CHEMBL507903 | — | — | 1 | 5.52 |
| CHEMBL502 | DONEPEZIL | 4.0 | 1 | 5.13 |
| CHEMBL254016 | — | — | 1 | 5.07 |
| CHEMBL450990 | — | — | 1 | 4.99 |
| CHEMBL502877 | — | — | 1 | 4.97 |
| CHEMBL11805 | CAPROCTAMINE | — | 1 | 4.94 |
| CHEMBL345124 | PROPIDIUM | — | 1 | 4.88 |
| CHEMBL659 | GALANTAMINE | 4.0 | 1 | 4.68 |
| CHEMBL499722 | — | — | 1 | 4.60 |
| CHEMBL499825 | — | — | 1 | 4.51 |
| CHEMBL450506 | — | — | 1 | 4.43 |
| CHEMBL429694 | CONGO RED | -1.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL452339 | — | IC50 | = | 95.8 | nM | 7.02 |
| CHEMBL507304 | — | IC50 | = | 293.0 | nM | 6.53 |
| CHEMBL488590 | — | IC50 | = | 416.0 | nM | 6.38 |
| CHEMBL449941 | — | IC50 | = | 876.0 | nM | 6.06 |
| CHEMBL507885 | — | IC50 | = | 1040.0 | nM | 5.98 |
| CHEMBL450553 | — | IC50 | = | 1910.0 | nM | 5.72 |
| CHEMBL449467 | — | IC50 | = | 2090.0 | nM | 5.68 |
| CHEMBL173309 | — | IC50 | = | 2250.0 | nM | 5.65 |
| CHEMBL507903 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL502 | DONEPEZIL | IC50 | = | 7420.0 | nM | 5.13 |
| CHEMBL254016 | — | IC50 | = | 8490.0 | nM | 5.07 |
| CHEMBL450990 | — | IC50 | = | 10300.0 | nM | 4.99 |
| CHEMBL502877 | — | IC50 | = | 10700.0 | nM | 4.97 |
| CHEMBL11805 | CAPROCTAMINE | IC50 | = | 11600.0 | nM | 4.94 |
| CHEMBL345124 | PROPIDIUM | IC50 | = | 13200.0 | nM | 4.88 |
| CHEMBL659 | GALANTAMINE | IC50 | = | 20700.0 | nM | 4.68 |
| CHEMBL499722 | — | IC50 | = | 25300.0 | nM | 4.60 |
| CHEMBL499825 | — | IC50 | = | 30800.0 | nM | 4.51 |
| CHEMBL450506 | — | IC50 | = | 36800.0 | nM | 4.43 |
| CHEMBL429694 | CONGO RED | Activity | - | — | - |