Assay Detail
Binding
CHEMBL948494
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of radiolabeled Dexamethasone from human glucocorticoid receptor by filter paper assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Indazole-based liver X receptor (LXR) modulators with maintained atherosclerotic lesion reduction activity but diminished stimulation of hepatic triglyceride synthesis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 5.57 | 6.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL456237 | LXR-623 | 1.0 | 1 | 6.00 |
| CHEMBL457977 | — | — | 1 | 5.14 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL456237 | LXR-623 | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL457977 | — | IC50 | = | 7200.0 | nM | 5.14 |