Assay Detail
Binding
CHEMBL948823
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Inhibition of GST-tagged IGF1R (957-1367) expressed in baculovirus by time-resolved fluorescence assay
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Target
Insulin-like growth factor 1 receptor (CHEMBL1957) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery and optimization of imidazo[1,2-a]pyridine inhibitors of insulin-like growth factor-1 receptor (IGF-1R).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 8.25 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL448668 | — | — | 1 | 9.00 |
| CHEMBL500198 | — | — | 1 | 9.00 |
| CHEMBL447668 | — | — | 1 | 8.70 |
| CHEMBL453438 | — | — | 1 | 8.70 |
| CHEMBL506862 | — | — | 1 | 8.70 |
| CHEMBL502652 | — | — | 1 | 8.70 |
| CHEMBL502198 | — | — | 1 | 8.70 |
| CHEMBL508627 | — | — | 1 | 8.70 |
| CHEMBL449110 | — | — | 1 | 8.70 |
| CHEMBL447639 | — | — | 1 | 8.52 |
| CHEMBL500003 | — | — | 1 | 8.40 |
| CHEMBL454796 | — | — | 1 | 8.40 |
| CHEMBL507714 | — | — | 1 | 8.30 |
| CHEMBL444031 | — | — | 1 | 8.15 |
| CHEMBL448929 | — | — | 1 | 8.15 |
| CHEMBL447450 | — | — | 1 | 8.00 |
| CHEMBL466397 | — | — | 1 | 7.57 |
| CHEMBL480544 | — | — | 1 | 7.55 |
| CHEMBL504398 | — | — | 1 | 6.75 |
| CHEMBL513227 | — | — | 1 | 6.36 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL448668 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL500198 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL447668 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL453438 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL506862 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL502652 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL502198 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL508627 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL449110 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL447639 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL500003 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL454796 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL507714 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL444031 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL448929 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL447450 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL466397 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL480544 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL504398 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL513227 | — | IC50 | = | 440.0 | nM | 6.36 |