Assay Detail
Binding
CHEMBL948824
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Inhibition of human IGF1R autophosphorylation in transfected mouse NIH3T3 cells
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | NIH3T3 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Insulin-like growth factor 1 receptor (CHEMBL1957) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery and optimization of imidazo[1,2-a]pyridine inhibitors of insulin-like growth factor-1 receptor (IGF-1R).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 6.93 | 7.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL466397 | — | — | 1 | 7.66 |
| CHEMBL449110 | — | — | 1 | 7.55 |
| CHEMBL507714 | — | — | 1 | 7.44 |
| CHEMBL506862 | — | — | 1 | 7.42 |
| CHEMBL502198 | — | — | 1 | 7.42 |
| CHEMBL508627 | — | — | 1 | 7.40 |
| CHEMBL502652 | — | — | 1 | 7.39 |
| CHEMBL447639 | — | — | 1 | 7.19 |
| CHEMBL454796 | — | — | 1 | 7.17 |
| CHEMBL453438 | — | — | 1 | 7.06 |
| CHEMBL500003 | — | — | 1 | 6.76 |
| CHEMBL448668 | — | — | 1 | 6.75 |
| CHEMBL447450 | — | — | 1 | 6.61 |
| CHEMBL500198 | — | — | 1 | 6.61 |
| CHEMBL447668 | — | — | 1 | 6.46 |
| CHEMBL444031 | — | — | 1 | 6.37 |
| CHEMBL480544 | — | — | 1 | 6.29 |
| CHEMBL504398 | — | — | 1 | 5.23 |
| CHEMBL513227 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL466397 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL449110 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL507714 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL506862 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL502198 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL508627 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL502652 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL447639 | — | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL454796 | — | IC50 | = | 68.0 | nM | 7.17 |
| CHEMBL453438 | — | IC50 | = | 87.0 | nM | 7.06 |
| CHEMBL500003 | — | IC50 | = | 174.0 | nM | 6.76 |
| CHEMBL448668 | — | IC50 | = | 177.0 | nM | 6.75 |
| CHEMBL447450 | — | IC50 | = | 247.0 | nM | 6.61 |
| CHEMBL500198 | — | IC50 | = | 244.0 | nM | 6.61 |
| CHEMBL447668 | — | IC50 | = | 344.0 | nM | 6.46 |
| CHEMBL444031 | — | IC50 | = | 431.0 | nM | 6.37 |
| CHEMBL480544 | — | IC50 | = | 509.0 | nM | 6.29 |
| CHEMBL504398 | — | IC50 | = | 5930.0 | nM | 5.23 |
| CHEMBL513227 | — | IC50 | > | 30000.0 | nM | - |