Assay Detail
Binding
CHEMBL948832
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]PSB-603 from human recombinant adenosine A2B receptor expressed in CHO cells
35
Total Activities
35
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
1-alkyl-8-(piperazine-1-sulfonyl)phenylxanthines: development and characterization of adenosine A2B receptor antagonists and a new radioligand with subnanomolar affinity and subtype specificity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 35 | 8.52 | 9.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL486478 | — | — | 1 | 9.80 |
| CHEMBL483261 | — | — | 1 | 9.67 |
| CHEMBL519390 | — | — | 1 | 9.55 |
| CHEMBL486479 | — | — | 1 | 9.52 |
| CHEMBL482436 | — | — | 1 | 9.41 |
| CHEMBL483487 | — | — | 1 | 9.39 |
| CHEMBL484900 | — | — | 1 | 9.35 |
| CHEMBL519253 | — | — | 1 | 9.32 |
| CHEMBL483688 | — | — | 1 | 9.26 |
| CHEMBL520830 | — | — | 1 | 9.22 |
| CHEMBL482638 | — | — | 1 | 9.21 |
| CHEMBL484899 | — | — | 1 | 9.16 |
| CHEMBL483469 | — | — | 1 | 9.11 |
| CHEMBL486688 | — | — | 1 | 9.11 |
| CHEMBL518972 | — | — | 1 | 9.07 |
| CHEMBL483065 | — | — | 1 | 9.06 |
| CHEMBL482855 | — | — | 1 | 9.03 |
| CHEMBL486893 | — | — | 1 | 8.97 |
| CHEMBL519813 | — | — | 1 | 8.94 |
| CHEMBL482648 | — | — | 1 | 8.92 |
| CHEMBL520297 | — | — | 1 | 8.90 |
| CHEMBL212625 | — | — | 1 | 8.88 |
| CHEMBL520617 | — | — | 1 | 8.80 |
| CHEMBL486481 | — | — | 1 | 8.70 |
| CHEMBL486282 | — | — | 1 | 8.52 |
| CHEMBL488542 | — | — | 1 | 8.27 |
| CHEMBL519556 | — | — | 1 | 8.13 |
| CHEMBL488541 | — | — | 1 | 8.12 |
| CHEMBL520899 | — | — | 1 | 7.93 |
| CHEMBL486281 | — | — | 1 | 7.71 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL486478 | — | Ki | = | 0.157 | nM | 9.80 |
| CHEMBL483261 | — | Ki | = | 0.215 | nM | 9.67 |
| CHEMBL519390 | — | Ki | = | 0.281 | nM | 9.55 |
| CHEMBL486479 | — | Ki | = | 0.303 | nM | 9.52 |
| CHEMBL482436 | — | Ki | = | 0.393 | nM | 9.41 |
| CHEMBL483487 | — | Ki | = | 0.406 | nM | 9.39 |
| CHEMBL484900 | — | Ki | = | 0.446 | nM | 9.35 |
| CHEMBL519253 | — | Ki | = | 0.473 | nM | 9.32 |
| CHEMBL483688 | — | Ki | = | 0.553 | nM | 9.26 |
| CHEMBL520830 | — | Ki | = | 0.595 | nM | 9.22 |
| CHEMBL482638 | — | Ki | = | 0.61 | nM | 9.21 |
| CHEMBL484899 | — | Ki | = | 0.695 | nM | 9.16 |
| CHEMBL483469 | — | Ki | = | 0.782 | nM | 9.11 |
| CHEMBL486688 | — | Ki | = | 0.775 | nM | 9.11 |
| CHEMBL518972 | — | Ki | = | 0.858 | nM | 9.07 |
| CHEMBL483065 | — | Ki | = | 0.875 | nM | 9.06 |
| CHEMBL482855 | — | Ki | = | 0.944 | nM | 9.03 |
| CHEMBL486893 | — | Ki | = | 1.06 | nM | 8.97 |
| CHEMBL519813 | — | Ki | = | 1.15 | nM | 8.94 |
| CHEMBL482648 | — | Ki | = | 1.19 | nM | 8.92 |
| CHEMBL520297 | — | Ki | = | 1.27 | nM | 8.90 |
| CHEMBL212625 | — | Ki | = | 1.33 | nM | 8.88 |
| CHEMBL520617 | — | Ki | = | 1.58 | nM | 8.80 |
| CHEMBL486481 | — | Ki | = | 1.99 | nM | 8.70 |
| CHEMBL486282 | — | Ki | = | 3.03 | nM | 8.52 |
| CHEMBL488542 | — | Ki | = | 5.43 | nM | 8.27 |
| CHEMBL519556 | — | Ki | = | 7.49 | nM | 8.13 |
| CHEMBL488541 | — | Ki | = | 7.51 | nM | 8.12 |
| CHEMBL520899 | — | Ki | = | 11.7 | nM | 7.93 |
| CHEMBL486281 | — | Ki | = | 19.7 | nM | 7.71 |
| CHEMBL16687 | CGS-15943 | Ki | = | 30.0 | nM | 7.52 |
| CHEMBL452924 | — | Ki | = | 237.0 | nM | 6.62 |
| CHEMBL464859 | NECA | Ki | = | 1890.0 | nM | 5.72 |
| CHEMBL285819 | — | Ki | = | 21400.0 | nM | 4.67 |
| CHEMBL113 | CAFFEINE | Ki | = | 33800.0 | nM | 4.47 |