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Compound Detail

CHEMBL520899

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CCn1c(=O)[nH]c2nc(-c3ccc(S(=O)(=O)N4CCN(c5ccc(OC)cc5)CC4)cc3)[nH]c2c1=O

Basic Information

ChEMBL ID CHEMBL520899
Phase Preclinical
Structure Type MOL
InChI Key HJXIYSAOVDGJOJ-UHFFFAOYSA-N
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names

Molecular Properties

510.6
MW (Da)
1.62
ALogP
8
HBA
2
HBD
133.4
PSA (Ų)
0.40
QED
1
Ro5 Violations
6
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C24H26N6O5S
MW 510.58
Aromatic Rings 4
Heavy Atoms 36
NP-Likeness -1.49

Activity Summary

Ki 2 meas. best 7.93

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Adenosine receptor A2b
CHEMBL255
Ki 7.93 7.93 11.7 1
Adenosine receptor A2a
CHEMBL302
Ki 6.43 6.43 367.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
19569717 10.1021/jm900413e Adenosine receptor A1 3
19569717 10.1021/jm900413e Adenosine receptor A2a 2
19569717 10.1021/jm900413e Adenosine receptor A2b 2
19569717 10.1021/jm900413e Adenosine receptor A3 2

Data from ChEMBL 36 via Core Engine