Assay Detail
Binding
CHEMBL948917
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Inhibition of human alpha-thrombin
101
Total Activities
99
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Inhibitors of proteases and amide hydrolases that employ an alpha-ketoheterocycle as a key enabling functionality.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 55 | 8.19 | 10.15 |
| IC50 | 46 | 6.10 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL284549 | — | — | 1 | 10.15 |
| CHEMBL404043 | — | — | 1 | 9.85 |
| CHEMBL404042 | — | — | 1 | 9.82 |
| CHEMBL270437 | — | — | 1 | 9.70 |
| CHEMBL256253 | — | — | 1 | 9.70 |
| CHEMBL341581 | — | — | 1 | 9.38 |
| CHEMBL324413 | — | — | 2 | 9.22 |
| CHEMBL270225 | — | — | 1 | 9.19 |
| CHEMBL256631 | — | — | 1 | 9.15 |
| CHEMBL361379 | — | — | 1 | 9.10 |
| CHEMBL283717 | — | — | 1 | 9.07 |
| CHEMBL438351 | — | — | 1 | 9.00 |
| CHEMBL366688 | — | — | 1 | 9.00 |
| CHEMBL333154 | — | — | 1 | 9.00 |
| CHEMBL139242 | — | — | 1 | 8.96 |
| CHEMBL403735 | — | — | 1 | 8.96 |
| CHEMBL402378 | — | — | 1 | 8.92 |
| CHEMBL272334 | — | — | 1 | 8.89 |
| CHEMBL257898 | — | — | 1 | 8.85 |
| CHEMBL401737 | — | — | 1 | 8.82 |
| CHEMBL366625 | — | — | 1 | 8.80 |
| CHEMBL403929 | — | — | 1 | 8.70 |
| CHEMBL344916 | — | — | 1 | 8.70 |
| CHEMBL322205 | — | — | 1 | 8.68 |
| CHEMBL32182 | — | — | 1 | 8.62 |
| CHEMBL137945 | — | — | 1 | 8.59 |
| CHEMBL401696 | — | — | 1 | 8.49 |
| CHEMBL102121 | — | — | 1 | 8.47 |
| CHEMBL336048 | — | — | 1 | 8.46 |
| CHEMBL270206 | — | — | 1 | 8.35 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL284549 | — | Ki | = | 0.071 | nM | 10.15 |
| CHEMBL404043 | — | Ki | = | 0.14 | nM | 9.85 |
| CHEMBL404042 | — | Ki | = | 0.15 | nM | 9.82 |
| CHEMBL270437 | — | Ki | = | 0.2 | nM | 9.70 |
| CHEMBL256253 | — | Ki | = | 0.2 | nM | 9.70 |
| CHEMBL341581 | — | Ki | = | 0.42 | nM | 9.38 |
| CHEMBL324413 | — | Ki | = | 0.6 | nM | 9.22 |
| CHEMBL270225 | — | Ki | = | 0.65 | nM | 9.19 |
| CHEMBL256631 | — | Ki | = | 0.7 | nM | 9.15 |
| CHEMBL361379 | — | Ki | = | 0.8 | nM | 9.10 |
| CHEMBL283717 | — | Ki | = | 0.85 | nM | 9.07 |
| CHEMBL366688 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL438351 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL333154 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL403735 | — | Ki | = | 1.1 | nM | 8.96 |
| CHEMBL139242 | — | Ki | = | 1.1 | nM | 8.96 |
| CHEMBL402378 | — | Ki | = | 1.2 | nM | 8.92 |
| CHEMBL272334 | — | Ki | = | 1.3 | nM | 8.89 |
| CHEMBL257898 | — | Ki | = | 1.4 | nM | 8.85 |
| CHEMBL401737 | — | Ki | = | 1.5 | nM | 8.82 |
| CHEMBL366625 | — | Ki | = | 1.6 | nM | 8.80 |
| CHEMBL403929 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL344916 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL322205 | — | Ki | = | 2.1 | nM | 8.68 |
| CHEMBL32182 | — | Ki | = | 2.4 | nM | 8.62 |
| CHEMBL137945 | — | Ki | = | 2.6 | nM | 8.59 |
| CHEMBL401696 | — | Ki | = | 3.2 | nM | 8.49 |
| CHEMBL102121 | — | Ki | = | 3.4 | nM | 8.47 |
| CHEMBL336048 | — | Ki | = | 3.5 | nM | 8.46 |
| CHEMBL270206 | — | Ki | = | 4.5 | nM | 8.35 |
| CHEMBL258108 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL324413 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL256027 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL105584 | — | Ki | = | 6.2 | nM | 8.21 |
| CHEMBL257068 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL256381 | — | Ki | = | 8.1 | nM | 8.09 |
| CHEMBL265317 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL256393 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL269971 | — | Ki | = | 16.0 | nM | 7.80 |
| CHEMBL175464 | — | Ki | = | 17.0 | nM | 7.77 |
| CHEMBL273196 | EFEGATRAN | Ki | = | 18.0 | nM | 7.75 |
| CHEMBL256025 | — | Ki | = | 18.0 | nM | 7.75 |
| CHEMBL255973 | — | Ki | = | 18.0 | nM | 7.75 |
| CHEMBL256394 | — | Ki | = | 24.0 | nM | 7.62 |
| CHEMBL369868 | — | Ki | = | 38.0 | nM | 7.42 |
| CHEMBL271495 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL404268 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL275859 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL256396 | — | IC50 | = | 51.0 | nM | 7.29 |
| CHEMBL404654 | — | Ki | = | 55.0 | nM | 7.26 |