Assay Detail
Binding
CHEMBL948933
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Inhibition of kallikrein
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Inhibitors of proteases and amide hydrolases that employ an alpha-ketoheterocycle as a key enabling functionality.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.64 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL413155 | — | — | 1 | 8.00 |
| CHEMBL270834 | — | — | 1 | 7.89 |
| CHEMBL414002 | — | — | 1 | 7.85 |
| CHEMBL271047 | — | — | 1 | 7.54 |
| CHEMBL256427 | — | — | 1 | 6.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL413155 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL270834 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL414002 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL271047 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL256427 | — | IC50 | = | 120.0 | nM | 6.92 |