Assay Detail
Binding
CHEMBL948936
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Inhibition of human factor 11a
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Inhibitors of proteases and amide hydrolases that employ an alpha-ketoheterocycle as a key enabling functionality.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 7.05 | 8.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL413155 | — | — | 1 | 8.22 |
| CHEMBL269969 | — | — | 1 | 8.00 |
| CHEMBL273653 | — | — | 1 | 7.52 |
| CHEMBL375599 | — | — | 1 | 7.35 |
| CHEMBL266570 | — | — | 1 | 7.20 |
| CHEMBL270204 | — | — | 1 | 7.03 |
| CHEMBL403113 | — | — | 1 | 6.92 |
| CHEMBL429733 | — | — | 1 | 6.60 |
| CHEMBL257315 | — | — | 1 | 6.32 |
| CHEMBL271508 | — | — | 1 | 6.30 |
| CHEMBL255407 | — | — | 1 | 6.07 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL413155 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL269969 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL273653 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL375599 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL266570 | — | IC50 | = | 63.0 | nM | 7.20 |
| CHEMBL270204 | — | IC50 | = | 93.0 | nM | 7.03 |
| CHEMBL403113 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL429733 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL257315 | — | IC50 | = | 480.0 | nM | 6.32 |
| CHEMBL271508 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL255407 | — | IC50 | = | 850.0 | nM | 6.07 |