Assay Detail
Binding
CHEMBL948937
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Inhibition of human factor 7a
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Inhibitors of proteases and amide hydrolases that employ an alpha-ketoheterocycle as a key enabling functionality.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 6.74 | 7.38 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL78055 | — | — | 1 | 7.38 |
| CHEMBL311553 | — | — | 1 | 7.05 |
| CHEMBL275859 | — | — | 1 | 6.96 |
| CHEMBL78053 | — | — | 1 | 6.70 |
| CHEMBL308948 | — | — | 1 | 6.54 |
| CHEMBL402935 | — | — | 1 | 6.52 |
| CHEMBL257867 | — | — | 1 | 6.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL78055 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL311553 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL275859 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL78053 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL308948 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL402935 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL257867 | — | IC50 | = | 1000.0 | nM | 6.00 |