Assay Detail
Binding
CHEMBL948992
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Inhibition of Tie2
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
N-(3-(phenylcarbamoyl)arylpyrimidine)-5-carboxamides as potent and selective inhibitors of Lck: structure, synthesis and SAR.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 7.08 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL385937 | — | — | 1 | 8.70 |
| CHEMBL257858 | — | — | 1 | 5.46 |
| CHEMBL271018 | — | — | 1 | - |
| CHEMBL269936 | — | — | 1 | - |
| CHEMBL255132 | — | — | 1 | - |
| CHEMBL255989 | — | — | 1 | - |
| CHEMBL270793 | — | — | 1 | - |
| CHEMBL271650 | — | — | 1 | - |
| CHEMBL408292 | — | — | 1 | - |
| CHEMBL271099 | — | — | 1 | - |
| CHEMBL271101 | — | — | 1 | - |
| CHEMBL255533 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL385937 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL257858 | — | IC50 | = | 3440.0 | nM | 5.46 |
| CHEMBL271018 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL269936 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL255132 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL255989 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL270793 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL271650 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL408292 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL271099 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL271101 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL255533 | — | IC50 | > | 25000.0 | nM | - |