Assay Detail
Functional
CHEMBL948993
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Inhibition of T cell activation in human mixed lymphocyte reaction
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | T-cell |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
N-(3-(phenylcarbamoyl)arylpyrimidine)-5-carboxamides as potent and selective inhibitors of Lck: structure, synthesis and SAR.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 5.95 | 6.97 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL257858 | — | — | 1 | 6.97 |
| CHEMBL255989 | — | — | 1 | 5.57 |
| CHEMBL270793 | — | — | 1 | 5.31 |
| CHEMBL271018 | — | — | 1 | - |
| CHEMBL408292 | — | — | 1 | - |
| CHEMBL271099 | — | — | 1 | - |
| CHEMBL271101 | — | — | 1 | - |
| CHEMBL255533 | — | — | 1 | - |
| CHEMBL271650 | — | — | 1 | - |
| CHEMBL269936 | — | — | 1 | - |
| CHEMBL255132 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL257858 | — | IC50 | = | 107.0 | nM | 6.97 |
| CHEMBL255989 | — | IC50 | = | 2710.0 | nM | 5.57 |
| CHEMBL270793 | — | IC50 | = | 4920.0 | nM | 5.31 |
| CHEMBL271018 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL408292 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL271099 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL271101 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL255533 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL271650 | — | IC50 | - | — | - | |
| CHEMBL269936 | — | IC50 | - | — | - | |
| CHEMBL255132 | — | IC50 | - | — | - |