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Assay Detail

CHEMBL948999

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiviral activity against HIV1RF infected in human CEM-SS cells
17
Total Activities
17
Compounds Tested
2
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Human immunodeficiency virus 1
Cell Type CEM-SS
Confidence 1 — Organism
Curated By Intermediate

Target

Human immunodeficiency virus 1 (CHEMBL378)
Type ORGANISM
Organism Human immunodeficiency virus 1

Publication

Inhibition of tubulin polymerization by select alkenyldiarylmethanes.
Cullen MD, Sarkar T, Hamel E, Hartman TL, Watson KM, Buckheit RW, Pannecouque C, De Clercq E, Cushman M.
Bioorg Med Chem Lett (2008) 18 : 469 -473
PubMed 18083556 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 9 6.02 8.82
Activity 8 - -

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL57 NEVIRAPINE 4.0 1 8.82
CHEMBL294840 1 7.89
CHEMBL242844 1 5.64
CHEMBL255525 1 5.54
CHEMBL108267 1 5.09
CHEMBL110175 1 4.89
CHEMBL130984 1 4.28
CHEMBL107 COLCHICINE 4.0 1 -
CHEMBL110359 1 -
CHEMBL389237 1 -
CHEMBL403246 1 -
CHEMBL403462 1 -
CHEMBL437782 1 -
CHEMBL387804 1 -
CHEMBL67 COMBRETASTATIN A4 -1.0 1 -
CHEMBL256806 1 -
CHEMBL398201 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL57 NEVIRAPINE EC50 = 1.5 nM 8.82
CHEMBL294840 EC50 = 13.0 nM 7.89
CHEMBL242844 EC50 = 2300.0 nM 5.64
CHEMBL255525 EC50 = 2900.0 nM 5.54
CHEMBL108267 EC50 = 8200.0 nM 5.09
CHEMBL110175 EC50 = 13000.0 nM 4.89
CHEMBL130984 EC50 = 53000.0 nM 4.28
CHEMBL107 COLCHICINE EC50 - -
CHEMBL110359 Activity - -
CHEMBL389237 Activity - -
CHEMBL403246 Activity - -
CHEMBL403462 Activity - -
CHEMBL437782 Activity - -
CHEMBL387804 Activity - -
CHEMBL67 COMBRETASTATIN A4 EC50 - -
CHEMBL256806 Activity - -
CHEMBL398201 Activity - -