Assay Detail
Binding
CHEMBL949042
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Inhibition of human Wee1
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and structure-activity relationships of soluble 8-substituted 4-(2-chlorophenyl)-9-hydroxypyrrolo[3,4-c]carbazole-1,3(2H,6H)-diones as inhibitors of the Wee1 and Chk1 checkpoint kinases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 24 | 7.48 | 8.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL411662 | — | — | 1 | 8.05 |
| CHEMBL272267 | — | — | 1 | 7.82 |
| CHEMBL271715 | — | — | 1 | 7.82 |
| CHEMBL401776 | — | — | 1 | 7.75 |
| CHEMBL258067 | — | — | 1 | 7.72 |
| CHEMBL404335 | — | — | 1 | 7.70 |
| CHEMBL270021 | — | — | 1 | 7.62 |
| CHEMBL255565 | — | — | 1 | 7.62 |
| CHEMBL256480 | — | — | 1 | 7.58 |
| CHEMBL272479 | — | — | 1 | 7.58 |
| CHEMBL438566 | — | — | 1 | 7.52 |
| CHEMBL270866 | — | — | 1 | 7.48 |
| CHEMBL255416 | — | — | 1 | 7.47 |
| CHEMBL271071 | — | — | 1 | 7.46 |
| CHEMBL271084 | — | — | 1 | 7.44 |
| CHEMBL403679 | — | — | 1 | 7.43 |
| CHEMBL402093 | — | — | 1 | 7.34 |
| CHEMBL401746 | — | — | 1 | 7.31 |
| CHEMBL272946 | — | — | 1 | 7.30 |
| CHEMBL410261 | — | — | 1 | 7.24 |
| CHEMBL272351 | — | — | 1 | 7.24 |
| CHEMBL255427 | — | — | 1 | 7.12 |
| CHEMBL214253 | — | — | 1 | 7.01 |
| CHEMBL257857 | — | — | 1 | 6.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL411662 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL272267 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL271715 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL401776 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL258067 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL404335 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL270021 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL255565 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL256480 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL272479 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL438566 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL270866 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL255416 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL271071 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL271084 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL403679 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL402093 | — | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL401746 | — | IC50 | = | 49.0 | nM | 7.31 |
| CHEMBL272946 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL410261 | — | IC50 | = | 58.0 | nM | 7.24 |
| CHEMBL272351 | — | IC50 | = | 57.0 | nM | 7.24 |
| CHEMBL255427 | — | IC50 | = | 75.0 | nM | 7.12 |
| CHEMBL214253 | — | IC50 | = | 97.0 | nM | 7.01 |
| CHEMBL257857 | — | IC50 | = | 160.0 | nM | 6.80 |