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Assay Detail

CHEMBL949102

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Functional
Inhibition of human HT1080 cells
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type HT-1080
Confidence 1 — Organism
Curated By Autocuration

Target

HT-1080 (CHEMBL614580)
Type CELL-LINE
Organism Homo sapiens

Publication

Histone deacetylase inhibitors: from bench to clinic.
Paris M, Porcelloni M, Binaschi M, Fattori D.
J Med Chem (2008) 51 : 1505 -1529
PubMed 18247554 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 20 7.94 9.51

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL123626 1 9.51
CHEMBL124650 1 9.18
CHEMBL126274 1 8.88
CHEMBL435415 1 8.70
CHEMBL340885 1 8.62
CHEMBL126273 1 8.62
CHEMBL98 VORINOSTAT 4.0 1 8.62
CHEMBL124282 1 8.44
CHEMBL124593 1 8.29
CHEMBL124909 1 8.29
CHEMBL340835 1 8.25
CHEMBL339720 1 8.11
CHEMBL127846 1 8.07
CHEMBL125042 1 8.00
CHEMBL339796 1 7.82
CHEMBL123905 1 7.57
CHEMBL113033 1 6.92
CHEMBL271800 1 6.17
CHEMBL324429 1 5.57
CHEMBL112446 1 5.16

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL123626 IC50 = 0.31 nM 9.51
CHEMBL124650 IC50 = 0.66 nM 9.18
CHEMBL126274 IC50 = 1.32 nM 8.88
CHEMBL435415 IC50 = 2.0 nM 8.70
CHEMBL340885 IC50 = 2.39 nM 8.62
CHEMBL126273 IC50 = 2.39 nM 8.62
CHEMBL98 VORINOSTAT IC50 = 2.4 nM 8.62
CHEMBL124282 IC50 = 3.63 nM 8.44
CHEMBL124593 IC50 = 5.14 nM 8.29
CHEMBL124909 IC50 = 5.07 nM 8.29
CHEMBL340835 IC50 = 5.68 nM 8.25
CHEMBL339720 IC50 = 7.7 nM 8.11
CHEMBL127846 IC50 = 8.41 nM 8.07
CHEMBL125042 IC50 = 10.1 nM 8.00
CHEMBL339796 IC50 = 15.3 nM 7.82
CHEMBL123905 IC50 = 27.0 nM 7.57
CHEMBL113033 IC50 = 120.0 nM 6.92
CHEMBL271800 IC50 = 670.0 nM 6.17
CHEMBL324429 IC50 = 2700.0 nM 5.57
CHEMBL112446 IC50 = 6900.0 nM 5.16