Assay Detail
Functional
CHEMBL949108
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human CEM cells assessed as viability
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CCRF-CEM |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Histone deacetylase inhibitors: from bench to clinic.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 5.42 | 5.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 5.72 |
| CHEMBL198350 | — | — | 1 | 5.58 |
| CHEMBL201710 | — | — | 1 | 5.47 |
| CHEMBL201131 | — | — | 1 | 4.91 |
| CHEMBL203028 | — | — | 1 | - |
| CHEMBL371212 | — | — | 1 | - |
| CHEMBL200980 | — | — | 1 | - |
| CHEMBL203207 | — | — | 1 | - |
| CHEMBL201473 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL98 | VORINOSTAT | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL198350 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL201710 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL201131 | — | IC50 | = | 12300.0 | nM | 4.91 |
| CHEMBL203028 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL371212 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL200980 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL203207 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL201473 | — | IC50 | > | 25000.0 | nM | - |