Assay Detail
Binding
CHEMBL949109
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Inhibition of mouse liver HDAC1
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Histone deacetylase inhibitors: from bench to clinic.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 7.40 | 8.74 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL99 | TRICHOSTATIN | 1.0 | 1 | 8.74 |
| CHEMBL261831 | — | — | 1 | 7.41 |
| CHEMBL217494 | — | — | 1 | 7.40 |
| CHEMBL218027 | — | — | 1 | 6.99 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 6.95 |
| CHEMBL272024 | — | — | 1 | 6.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL99 | TRICHOSTATIN | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL261831 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL217494 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL218027 | — | IC50 | = | 103.0 | nM | 6.99 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 112.0 | nM | 6.95 |
| CHEMBL272024 | — | IC50 | = | 121.0 | nM | 6.92 |