Assay Detail
Binding
CHEMBL949127
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Inhibition of rat FAAH
47
Total Activities
47
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Inhibitors of proteases and amide hydrolases that employ an alpha-ketoheterocycle as a key enabling functionality.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 47 | 8.00 | 9.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL175854 | — | — | 1 | 9.70 |
| CHEMBL272111 | — | — | 1 | 9.70 |
| CHEMBL178398 | — | — | 1 | 9.54 |
| CHEMBL220770 | — | — | 1 | 9.40 |
| CHEMBL426967 | — | — | 1 | 9.25 |
| CHEMBL257307 | — | — | 1 | 9.24 |
| CHEMBL219658 | — | — | 1 | 9.22 |
| CHEMBL257305 | — | — | 1 | 9.16 |
| CHEMBL255116 | — | — | 1 | 9.12 |
| CHEMBL373606 | — | — | 1 | 9.10 |
| CHEMBL220629 | — | — | 1 | 9.10 |
| CHEMBL361529 | — | — | 1 | 9.08 |
| CHEMBL371831 | — | — | 1 | 9.00 |
| CHEMBL178115 | — | — | 1 | 8.70 |
| CHEMBL177757 | — | — | 1 | 8.66 |
| CHEMBL35925 | — | — | 1 | 8.64 |
| CHEMBL178563 | — | — | 1 | 8.52 |
| CHEMBL272770 | — | — | 1 | 8.43 |
| CHEMBL176122 | — | — | 1 | 8.34 |
| CHEMBL177577 | — | — | 1 | 8.33 |
| CHEMBL367307 | — | — | 1 | 8.25 |
| CHEMBL257638 | — | — | 1 | 8.16 |
| CHEMBL366959 | — | — | 1 | 7.96 |
| CHEMBL175833 | — | — | 1 | 7.92 |
| CHEMBL272293 | — | — | 1 | 7.85 |
| CHEMBL362705 | — | — | 1 | 7.80 |
| CHEMBL39412 | — | — | 1 | 7.77 |
| CHEMBL426230 | — | — | 1 | 7.75 |
| CHEMBL373906 | — | — | 1 | 7.52 |
| CHEMBL366671 | — | — | 1 | 7.51 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL175854 | — | Ki | = | 0.2 | nM | 9.70 |
| CHEMBL272111 | — | Ki | = | 0.2 | nM | 9.70 |
| CHEMBL178398 | — | Ki | = | 0.29 | nM | 9.54 |
| CHEMBL220770 | — | Ki | = | 0.4 | nM | 9.40 |
| CHEMBL426967 | — | Ki | = | 0.56 | nM | 9.25 |
| CHEMBL257307 | — | Ki | = | 0.57 | nM | 9.24 |
| CHEMBL219658 | — | Ki | = | 0.6 | nM | 9.22 |
| CHEMBL257305 | — | Ki | = | 0.69 | nM | 9.16 |
| CHEMBL255116 | — | Ki | = | 0.75 | nM | 9.12 |
| CHEMBL373606 | — | Ki | = | 0.8 | nM | 9.10 |
| CHEMBL220629 | — | Ki | = | 0.8 | nM | 9.10 |
| CHEMBL361529 | — | Ki | = | 0.83 | nM | 9.08 |
| CHEMBL371831 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL178115 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL177757 | — | Ki | = | 2.2 | nM | 8.66 |
| CHEMBL35925 | — | Ki | = | 2.3 | nM | 8.64 |
| CHEMBL178563 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL272770 | — | Ki | = | 3.7 | nM | 8.43 |
| CHEMBL176122 | — | Ki | = | 4.6 | nM | 8.34 |
| CHEMBL177577 | — | Ki | = | 4.7 | nM | 8.33 |
| CHEMBL367307 | — | Ki | = | 5.6 | nM | 8.25 |
| CHEMBL257638 | — | Ki | = | 6.9 | nM | 8.16 |
| CHEMBL366959 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL175833 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL272293 | — | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL362705 | — | Ki | = | 16.0 | nM | 7.80 |
| CHEMBL39412 | — | Ki | = | 17.0 | nM | 7.77 |
| CHEMBL426230 | — | Ki | = | 18.0 | nM | 7.75 |
| CHEMBL373906 | — | Ki | = | 30.0 | nM | 7.52 |
| CHEMBL366671 | — | Ki | = | 31.0 | nM | 7.51 |
| CHEMBL402249 | — | Ki | = | 47.0 | nM | 7.33 |
| CHEMBL175021 | — | Ki | = | 49.0 | nM | 7.31 |
| CHEMBL402740 | — | Ki | = | 50.0 | nM | 7.30 |
| CHEMBL174048 | — | Ki | = | 54.0 | nM | 7.27 |
| CHEMBL267284 | — | Ki | = | 65.0 | nM | 7.19 |
| CHEMBL220938 | — | Ki | = | 80.0 | nM | 7.10 |
| CHEMBL178791 | — | Ki | = | 90.0 | nM | 7.05 |
| CHEMBL425684 | — | Ki | = | 120.0 | nM | 6.92 |
| CHEMBL220612 | — | Ki | = | 130.0 | nM | 6.89 |
| CHEMBL405089 | — | Ki | = | 130.0 | nM | 6.89 |
| CHEMBL426410 | — | Ki | = | 320.0 | nM | 6.50 |
| CHEMBL285678 | — | Ki | = | 370.0 | nM | 6.43 |
| CHEMBL177471 | — | Ki | = | 490.0 | nM | 6.31 |
| CHEMBL174951 | — | Ki | = | 3000.0 | nM | 5.52 |
| CHEMBL402875 | — | Ki | = | 3700.0 | nM | 5.43 |
| CHEMBL404102 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL271218 | — | Ki | > | 100000.0 | nM | - |