Assay Detail
Binding
CHEMBL949129
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Inhibition of human recombinant FAAH
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Inhibitors of proteases and amide hydrolases that employ an alpha-ketoheterocycle as a key enabling functionality.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 8.45 | 10.03 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL175854 | — | — | 1 | 10.03 |
| CHEMBL272111 | — | — | 1 | 9.59 |
| CHEMBL177577 | — | — | 1 | 8.05 |
| CHEMBL426230 | — | — | 1 | 8.00 |
| CHEMBL35925 | — | — | 1 | 7.89 |
| CHEMBL285678 | — | — | 1 | 7.14 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL175854 | — | Ki | = | 0.094 | nM | 10.03 |
| CHEMBL272111 | — | Ki | = | 0.26 | nM | 9.59 |
| CHEMBL177577 | — | Ki | = | 9.0 | nM | 8.05 |
| CHEMBL426230 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL35925 | — | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL285678 | — | Ki | = | 73.0 | nM | 7.14 |