Assay Detail
Binding
CHEMBL949173
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Inhibition of catalytic domain MMP9
31
Total Activities
31
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
beta-N-Biaryl ether sulfonamide hydroxamates as potent gelatinase inhibitors: part 1. Design, synthesis, and lead identification.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 31 | 7.13 | 8.42 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL404893 | — | — | 1 | 8.42 |
| CHEMBL398331 | — | — | 1 | 8.33 |
| CHEMBL401821 | — | — | 1 | 8.26 |
| CHEMBL404882 | — | — | 1 | 8.18 |
| CHEMBL252422 | — | — | 1 | 8.11 |
| CHEMBL429927 | — | — | 1 | 7.92 |
| CHEMBL403089 | — | — | 1 | 7.89 |
| CHEMBL252826 | — | — | 1 | 7.85 |
| CHEMBL411519 | — | — | 1 | 7.55 |
| CHEMBL403169 | — | — | 1 | 7.51 |
| CHEMBL270010 | — | — | 1 | 7.41 |
| CHEMBL403110 | — | — | 1 | 7.36 |
| CHEMBL272984 | — | — | 1 | 7.33 |
| CHEMBL258300 | — | — | 1 | 7.27 |
| CHEMBL408906 | — | — | 1 | 7.27 |
| CHEMBL270229 | — | — | 1 | 7.16 |
| CHEMBL272763 | — | — | 1 | 7.04 |
| CHEMBL270230 | — | — | 1 | 7.03 |
| CHEMBL429571 | — | — | 1 | 6.98 |
| CHEMBL270023 | — | — | 1 | 6.91 |
| CHEMBL257725 | — | — | 1 | 6.62 |
| CHEMBL258301 | — | — | 1 | 6.61 |
| CHEMBL270868 | — | — | 1 | 6.54 |
| CHEMBL402639 | — | — | 1 | 6.46 |
| CHEMBL404270 | — | — | 1 | 6.42 |
| CHEMBL269797 | — | — | 1 | 6.33 |
| CHEMBL257724 | — | — | 1 | 6.03 |
| CHEMBL256018 | — | — | 1 | 6.01 |
| CHEMBL402750 | — | — | 1 | 5.83 |
| CHEMBL256187 | — | — | 1 | 5.32 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL404893 | — | IC50 | = | 3.8 | nM | 8.42 |
| CHEMBL398331 | — | IC50 | = | 4.7 | nM | 8.33 |
| CHEMBL401821 | — | IC50 | = | 5.5 | nM | 8.26 |
| CHEMBL404882 | — | IC50 | = | 6.6 | nM | 8.18 |
| CHEMBL252422 | — | IC50 | = | 7.8 | nM | 8.11 |
| CHEMBL429927 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL403089 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL252826 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL411519 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL403169 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL270010 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL403110 | — | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL272984 | — | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL258300 | — | IC50 | = | 54.0 | nM | 7.27 |
| CHEMBL408906 | — | IC50 | = | 54.0 | nM | 7.27 |
| CHEMBL270229 | — | IC50 | = | 69.0 | nM | 7.16 |
| CHEMBL272763 | — | IC50 | = | 91.0 | nM | 7.04 |
| CHEMBL270230 | — | IC50 | = | 93.0 | nM | 7.03 |
| CHEMBL429571 | — | IC50 | = | 104.0 | nM | 6.98 |
| CHEMBL270023 | — | IC50 | = | 124.0 | nM | 6.91 |
| CHEMBL257725 | — | IC50 | = | 242.0 | nM | 6.62 |
| CHEMBL258301 | — | IC50 | = | 243.0 | nM | 6.61 |
| CHEMBL270868 | — | IC50 | = | 286.0 | nM | 6.54 |
| CHEMBL402639 | — | IC50 | = | 344.0 | nM | 6.46 |
| CHEMBL404270 | — | IC50 | = | 383.0 | nM | 6.42 |
| CHEMBL269797 | — | IC50 | = | 472.0 | nM | 6.33 |
| CHEMBL257724 | — | IC50 | = | 933.0 | nM | 6.03 |
| CHEMBL256018 | — | IC50 | = | 984.0 | nM | 6.01 |
| CHEMBL402750 | — | IC50 | = | 1489.0 | nM | 5.83 |
| CHEMBL256187 | — | IC50 | = | 4819.0 | nM | 5.32 |
| CHEMBL440398 | — | IC50 | > | 10000.0 | nM | - |