Assay Detail
Binding
CHEMBL949293
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Inhibition of human KDR phosphorylation in mouse NIH3T3 cells by ELISA
34
Total Activities
34
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | NIH3T3 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Vascular endothelial growth factor receptor 2 (CHEMBL279) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
3-amino-benzo[d]isoxazoles as novel multitargeted inhibitors of receptor tyrosine kinases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 31 | 7.44 | 8.52 |
| Activity | 3 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL409349 | — | — | 1 | 8.52 |
| CHEMBL410130 | — | — | 1 | 8.30 |
| CHEMBL272802 | — | — | 1 | 8.30 |
| CHEMBL269894 | — | — | 1 | 7.96 |
| CHEMBL271170 | — | — | 1 | 7.89 |
| CHEMBL271381 | — | — | 1 | 7.82 |
| CHEMBL272183 | — | — | 1 | 7.77 |
| CHEMBL269884 | — | — | 1 | 7.75 |
| CHEMBL273077 | — | — | 1 | 7.72 |
| CHEMBL270084 | — | — | 1 | 7.70 |
| CHEMBL270086 | — | — | 1 | 7.68 |
| CHEMBL406404 | — | — | 1 | 7.66 |
| CHEMBL406660 | — | — | 1 | 7.64 |
| CHEMBL411725 | — | — | 1 | 7.60 |
| CHEMBL271600 | — | — | 1 | 7.55 |
| CHEMBL430090 | — | — | 1 | 7.51 |
| CHEMBL270506 | — | — | 1 | 7.50 |
| CHEMBL272453 | — | — | 1 | 7.44 |
| CHEMBL260307 | — | — | 1 | 7.41 |
| CHEMBL410664 | — | — | 1 | 7.40 |
| CHEMBL272645 | — | — | 1 | 7.36 |
| CHEMBL271796 | — | — | 1 | 7.19 |
| CHEMBL271386 | — | — | 1 | 7.10 |
| CHEMBL269862 | — | — | 1 | 7.09 |
| CHEMBL410663 | — | — | 1 | 7.03 |
| CHEMBL269885 | — | — | 1 | 6.97 |
| CHEMBL271955 | — | — | 1 | 6.91 |
| CHEMBL269886 | — | — | 1 | 6.76 |
| CHEMBL273048 | — | — | 1 | 6.75 |
| CHEMBL410504 | — | — | 1 | 6.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL409349 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL410130 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL272802 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL269894 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL271170 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL271381 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL272183 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL269884 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL273077 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL270084 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL270086 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL406404 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL406660 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL411725 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL271600 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL430090 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL270506 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL272453 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL260307 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL410664 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL272645 | — | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL271796 | — | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL271386 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL269862 | — | IC50 | = | 81.0 | nM | 7.09 |
| CHEMBL410663 | — | IC50 | = | 94.0 | nM | 7.03 |
| CHEMBL269885 | — | IC50 | = | 106.0 | nM | 6.97 |
| CHEMBL271955 | — | IC50 | = | 123.0 | nM | 6.91 |
| CHEMBL269886 | — | IC50 | = | 173.0 | nM | 6.76 |
| CHEMBL273048 | — | IC50 | = | 179.0 | nM | 6.75 |
| CHEMBL410504 | — | IC50 | = | 497.0 | nM | 6.30 |
| CHEMBL409912 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL270489 | — | Activity | - | — | - | |
| CHEMBL270302 | — | Activity | - | — | - | |
| CHEMBL260305 | — | Activity | - | — | - |