Compound Detail
CHEMBL406404
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Cc1ccc(F)c(NC(=O)Nc2ccc(-c3ccc(OCCN4CCOCC4)c4onc(N)c34)cc2)c1
Basic Information
| ChEMBL ID | CHEMBL406404 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | YRDYSQQOGNXODJ-UHFFFAOYSA-N |
3
Targets
4
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
505.6
MW (Da)
4.88
ALogP
7
HBA
3
HBD
114.9
PSA (Ų)
0.33
QED
1
Ro5 Violations
7
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 4 meas. best 7.66
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Vascular endothelial growth factor receptor 2 CHEMBL279 | IC50 | 7.66 | 7.505 | 22.0 | 2 |
| Receptor-type tyrosine-protein kinase FLT3 CHEMBL1974 | IC50 | 7.47 | 7.47 | 34.0 | 1 |
| Mast/stem cell growth factor receptor Kit CHEMBL1936 | IC50 | 7.15 | 7.15 | 71.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Vascular endothelial growth factor receptor 2 | IC50 | = | 22.0 | nM | 7.66 | Inhibition of human KDR phosphorylation in mouse NIH3T3 cells by ELISA | 18260617 |
| Receptor-type tyrosine-protein kinase FLT3 | IC50 | = | 34.0 | nM | 7.47 | Inhibition of FLT3 by HTRF assay | 18260617 |
| Vascular endothelial growth factor receptor 2 | IC50 | = | 45.0 | nM | 7.35 | Inhibition of KDR by HTRF assay | 18260617 |
| Mast/stem cell growth factor receptor Kit | IC50 | = | 71.0 | nM | 7.15 | Inhibition of KIT by HTRF assay | 18260617 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 18260617 | 10.1021/jm701096v | Vascular endothelial growth factor receptor 2 | 2 |
| 18260617 | 10.1021/jm701096v | Mast/stem cell growth factor receptor Kit | 1 |
| 18260617 | 10.1021/jm701096v | Receptor-type tyrosine-protein kinase FLT3 | 1 |
Data from ChEMBL 36 via Core Engine