Assay Detail
Binding
CHEMBL949291
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Inhibition of FLT3 by HTRF assay
40
Total Activities
40
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Receptor-type tyrosine-protein kinase FLT3 (CHEMBL1974) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
3-amino-benzo[d]isoxazoles as novel multitargeted inhibitors of receptor tyrosine kinases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 33 | 7.35 | 8.40 |
| Activity | 7 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL406660 | — | — | 1 | 8.40 |
| CHEMBL272645 | — | — | 1 | 8.40 |
| CHEMBL272183 | — | — | 1 | 8.30 |
| CHEMBL271600 | — | — | 1 | 8.22 |
| CHEMBL411725 | — | — | 1 | 8.15 |
| CHEMBL410504 | — | — | 1 | 8.10 |
| CHEMBL272453 | — | — | 1 | 8.10 |
| CHEMBL410130 | — | — | 1 | 7.85 |
| CHEMBL271381 | — | — | 1 | 7.80 |
| CHEMBL409349 | — | — | 1 | 7.77 |
| CHEMBL430090 | — | — | 1 | 7.72 |
| CHEMBL273077 | — | — | 1 | 7.66 |
| CHEMBL271170 | — | — | 1 | 7.66 |
| CHEMBL271955 | — | — | 1 | 7.57 |
| CHEMBL410663 | — | — | 1 | 7.55 |
| CHEMBL269884 | — | — | 1 | 7.52 |
| CHEMBL406404 | — | — | 1 | 7.47 |
| CHEMBL270084 | — | — | 1 | 7.44 |
| CHEMBL270506 | — | — | 1 | 7.43 |
| CHEMBL273048 | — | — | 1 | 7.24 |
| CHEMBL409912 | — | — | 1 | 7.22 |
| CHEMBL260307 | — | — | 1 | 7.21 |
| CHEMBL271796 | — | — | 1 | 7.19 |
| CHEMBL407485 | — | — | 1 | 7.17 |
| CHEMBL270489 | — | — | 1 | 7.09 |
| CHEMBL260305 | — | — | 1 | 6.76 |
| CHEMBL271386 | — | — | 1 | 6.67 |
| CHEMBL270070 | — | — | 1 | 6.21 |
| CHEMBL272425 | — | — | 1 | 5.90 |
| CHEMBL270069 | — | — | 1 | 5.85 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL406660 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL272645 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL272183 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL271600 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL411725 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL410504 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL272453 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL410130 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL271381 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL409349 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL430090 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL273077 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL271170 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL271955 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL410663 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL269884 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL406404 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL270084 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL270506 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL273048 | — | IC50 | = | 58.0 | nM | 7.24 |
| CHEMBL409912 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL260307 | — | IC50 | = | 61.0 | nM | 7.21 |
| CHEMBL271796 | — | IC50 | = | 64.0 | nM | 7.19 |
| CHEMBL407485 | — | IC50 | = | 68.0 | nM | 7.17 |
| CHEMBL270489 | — | IC50 | = | 82.0 | nM | 7.09 |
| CHEMBL260305 | — | IC50 | = | 173.0 | nM | 6.76 |
| CHEMBL271386 | — | IC50 | = | 213.0 | nM | 6.67 |
| CHEMBL270070 | — | IC50 | = | 619.0 | nM | 6.21 |
| CHEMBL272425 | — | IC50 | = | 1260.0 | nM | 5.90 |
| CHEMBL270069 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL271795 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL270302 | — | IC50 | = | 1570.0 | nM | 5.80 |
| CHEMBL269894 | — | Activity | - | — | - | |
| CHEMBL270086 | — | Activity | - | — | - | |
| CHEMBL272802 | — | Activity | - | — | - | |
| CHEMBL269886 | — | Activity | - | — | - | |
| CHEMBL269885 | — | Activity | - | — | - | |
| CHEMBL410664 | — | Activity | - | — | - | |
| CHEMBL405370 | — | IC50 | > | 12500.0 | nM | - |
| CHEMBL269862 | — | Activity | - | — | - |