Assay Detail
Binding
CHEMBL949290
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Inhibition of KDR by HTRF assay
40
Total Activities
40
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Vascular endothelial growth factor receptor 2 (CHEMBL279) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
3-amino-benzo[d]isoxazoles as novel multitargeted inhibitors of receptor tyrosine kinases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 40 | 7.21 | 8.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL410130 | — | — | 1 | 8.15 |
| CHEMBL271381 | — | — | 1 | 8.10 |
| CHEMBL409349 | — | — | 1 | 8.10 |
| CHEMBL271600 | — | — | 1 | 8.10 |
| CHEMBL272453 | — | — | 1 | 8.10 |
| CHEMBL270506 | — | — | 1 | 8.10 |
| CHEMBL272802 | — | — | 1 | 8.00 |
| CHEMBL430090 | — | — | 1 | 7.96 |
| CHEMBL410664 | — | — | 1 | 7.82 |
| CHEMBL272645 | — | — | 1 | 7.80 |
| CHEMBL269894 | — | — | 1 | 7.77 |
| CHEMBL272183 | — | — | 1 | 7.72 |
| CHEMBL270084 | — | — | 1 | 7.68 |
| CHEMBL271170 | — | — | 1 | 7.68 |
| CHEMBL269885 | — | — | 1 | 7.66 |
| CHEMBL411725 | — | — | 1 | 7.64 |
| CHEMBL410663 | — | — | 1 | 7.64 |
| CHEMBL269886 | — | — | 1 | 7.50 |
| CHEMBL271796 | — | — | 1 | 7.43 |
| CHEMBL269884 | — | — | 1 | 7.39 |
| CHEMBL271955 | — | — | 1 | 7.38 |
| CHEMBL270086 | — | — | 1 | 7.36 |
| CHEMBL406404 | — | — | 1 | 7.35 |
| CHEMBL273077 | — | — | 1 | 7.23 |
| CHEMBL269862 | — | — | 1 | 7.17 |
| CHEMBL260307 | — | — | 1 | 7.15 |
| CHEMBL271386 | — | — | 1 | 6.98 |
| CHEMBL406660 | — | — | 1 | 6.87 |
| CHEMBL273048 | — | — | 1 | 6.80 |
| CHEMBL260305 | — | — | 1 | 6.68 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL410130 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL271381 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL270506 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL272453 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL409349 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL271600 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL272802 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL430090 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL410664 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL272645 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL269894 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL272183 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL270084 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL271170 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL269885 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL411725 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL410663 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL269886 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL271796 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL269884 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL271955 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL270086 | — | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL406404 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL273077 | — | IC50 | = | 59.0 | nM | 7.23 |
| CHEMBL269862 | — | IC50 | = | 67.0 | nM | 7.17 |
| CHEMBL260307 | — | IC50 | = | 71.0 | nM | 7.15 |
| CHEMBL271386 | — | IC50 | = | 104.0 | nM | 6.98 |
| CHEMBL406660 | — | IC50 | = | 134.0 | nM | 6.87 |
| CHEMBL273048 | — | IC50 | = | 158.0 | nM | 6.80 |
| CHEMBL260305 | — | IC50 | = | 211.0 | nM | 6.68 |
| CHEMBL272425 | — | IC50 | = | 247.0 | nM | 6.61 |
| CHEMBL410504 | — | IC50 | = | 318.0 | nM | 6.50 |
| CHEMBL270489 | — | IC50 | = | 365.0 | nM | 6.44 |
| CHEMBL271795 | — | IC50 | = | 628.0 | nM | 6.20 |
| CHEMBL409912 | — | IC50 | = | 806.0 | nM | 6.09 |
| CHEMBL270302 | — | IC50 | = | 6161.0 | nM | 5.21 |
| CHEMBL270070 | — | IC50 | = | 12500.0 | nM | 4.90 |
| CHEMBL407485 | — | IC50 | = | 18840.0 | nM | 4.72 |
| CHEMBL270069 | — | IC50 | > | 12500.0 | nM | - |
| CHEMBL405370 | — | IC50 | > | 12500.0 | nM | - |