Assay Detail
Binding
CHEMBL949292
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Inhibition of KIT by HTRF assay
40
Total Activities
40
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Mast/stem cell growth factor receptor Kit (CHEMBL1936) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
3-amino-benzo[d]isoxazoles as novel multitargeted inhibitors of receptor tyrosine kinases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 40 | 7.21 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL269894 | — | — | 1 | 8.40 |
| CHEMBL272645 | — | — | 1 | 8.30 |
| CHEMBL269885 | — | — | 1 | 8.30 |
| CHEMBL272802 | — | — | 1 | 8.15 |
| CHEMBL406660 | — | — | 1 | 8.15 |
| CHEMBL271600 | — | — | 1 | 8.00 |
| CHEMBL270086 | — | — | 1 | 7.96 |
| CHEMBL410130 | — | — | 1 | 7.92 |
| CHEMBL410664 | — | — | 1 | 7.92 |
| CHEMBL272183 | — | — | 1 | 7.85 |
| CHEMBL269862 | — | — | 1 | 7.85 |
| CHEMBL411725 | — | — | 1 | 7.75 |
| CHEMBL410504 | — | — | 1 | 7.68 |
| CHEMBL271381 | — | — | 1 | 7.64 |
| CHEMBL271170 | — | — | 1 | 7.64 |
| CHEMBL272453 | — | — | 1 | 7.62 |
| CHEMBL269886 | — | — | 1 | 7.57 |
| CHEMBL273077 | — | — | 1 | 7.44 |
| CHEMBL409349 | — | — | 1 | 7.43 |
| CHEMBL270084 | — | — | 1 | 7.37 |
| CHEMBL270506 | — | — | 1 | 7.30 |
| CHEMBL430090 | — | — | 1 | 7.25 |
| CHEMBL410663 | — | — | 1 | 7.21 |
| CHEMBL260307 | — | — | 1 | 7.19 |
| CHEMBL406404 | — | — | 1 | 7.15 |
| CHEMBL269884 | — | — | 1 | 7.14 |
| CHEMBL271955 | — | — | 1 | 6.99 |
| CHEMBL271796 | — | — | 1 | 6.94 |
| CHEMBL270489 | — | — | 1 | 6.94 |
| CHEMBL409912 | — | — | 1 | 6.78 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL269894 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL272645 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL269885 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL272802 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL406660 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL271600 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL270086 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL410130 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL410664 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL272183 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL269862 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL411725 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL410504 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL271381 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL271170 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL272453 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL269886 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL273077 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL409349 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL270084 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL270506 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL430090 | — | IC50 | = | 56.0 | nM | 7.25 |
| CHEMBL410663 | — | IC50 | = | 62.0 | nM | 7.21 |
| CHEMBL260307 | — | IC50 | = | 64.0 | nM | 7.19 |
| CHEMBL406404 | — | IC50 | = | 71.0 | nM | 7.15 |
| CHEMBL269884 | — | IC50 | = | 72.0 | nM | 7.14 |
| CHEMBL271955 | — | IC50 | = | 102.0 | nM | 6.99 |
| CHEMBL271796 | — | IC50 | = | 114.0 | nM | 6.94 |
| CHEMBL270489 | — | IC50 | = | 114.0 | nM | 6.94 |
| CHEMBL409912 | — | IC50 | = | 166.0 | nM | 6.78 |
| CHEMBL260305 | — | IC50 | = | 216.0 | nM | 6.67 |
| CHEMBL273048 | — | IC50 | = | 294.0 | nM | 6.53 |
| CHEMBL271386 | — | IC50 | = | 339.0 | nM | 6.47 |
| CHEMBL271795 | — | IC50 | = | 790.0 | nM | 6.10 |
| CHEMBL272425 | — | IC50 | = | 2630.0 | nM | 5.58 |
| CHEMBL270070 | — | IC50 | = | 4443.0 | nM | 5.35 |
| CHEMBL407485 | — | IC50 | = | 14800.0 | nM | 4.83 |
| CHEMBL270302 | — | IC50 | = | 23440.0 | nM | 4.63 |
| CHEMBL270069 | — | IC50 | > | 12500.0 | nM | - |
| CHEMBL405370 | — | IC50 | > | 12500.0 | nM | - |