Assay Detail
Binding
CHEMBL949477
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [125I]sauvagine from human recombinant CRF1 receptor expressed in CHO cells by SPA
44
Total Activities
44
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Corticotropin-releasing factor receptor 1 (CHEMBL1800) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Dihydropyrrole[2,3-d]pyridine derivatives as novel corticotropin-releasing factor-1 antagonists: mapping of the receptor binding pocket by in silico docking studies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 44 | 6.55 | 7.56 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL458968 | — | — | 1 | 7.56 |
| CHEMBL516175 | — | — | 1 | 7.46 |
| CHEMBL515843 | — | — | 1 | 7.40 |
| CHEMBL44698 | — | — | 1 | 7.40 |
| CHEMBL458825 | — | — | 1 | 7.27 |
| CHEMBL462789 | — | — | 1 | 7.25 |
| CHEMBL457714 | — | — | 1 | 7.23 |
| CHEMBL504383 | — | — | 1 | 7.22 |
| CHEMBL458824 | — | — | 1 | 7.06 |
| CHEMBL459006 | — | — | 1 | 7.03 |
| CHEMBL513967 | — | — | 1 | 7.00 |
| CHEMBL514761 | — | — | 1 | 6.94 |
| CHEMBL459007 | — | — | 1 | 6.90 |
| CHEMBL458826 | — | — | 1 | 6.89 |
| CHEMBL464390 | — | — | 1 | 6.84 |
| CHEMBL462788 | — | — | 1 | 6.80 |
| CHEMBL459174 | — | — | 1 | 6.79 |
| CHEMBL465216 | — | — | 1 | 6.76 |
| CHEMBL456651 | — | — | 1 | 6.67 |
| CHEMBL457741 | — | — | 1 | 6.65 |
| CHEMBL517910 | — | — | 1 | 6.64 |
| CHEMBL514126 | — | — | 1 | 6.59 |
| CHEMBL458101 | — | — | 1 | 6.59 |
| CHEMBL459181 | — | — | 1 | 6.50 |
| CHEMBL457740 | — | — | 1 | 6.44 |
| CHEMBL458353 | — | — | 1 | 6.37 |
| CHEMBL456241 | — | — | 1 | 6.07 |
| CHEMBL458981 | — | — | 1 | 5.69 |
| CHEMBL515070 | — | — | 1 | 5.63 |
| CHEMBL514272 | — | — | 1 | 5.56 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL458968 | — | IC50 | = | 27.54 | nM | 7.56 |
| CHEMBL516175 | — | IC50 | = | 34.67 | nM | 7.46 |
| CHEMBL44698 | — | IC50 | = | 39.81 | nM | 7.40 |
| CHEMBL515843 | — | IC50 | = | 39.81 | nM | 7.40 |
| CHEMBL458825 | — | IC50 | = | 53.7 | nM | 7.27 |
| CHEMBL462789 | — | IC50 | = | 56.23 | nM | 7.25 |
| CHEMBL457714 | — | IC50 | = | 58.88 | nM | 7.23 |
| CHEMBL504383 | — | IC50 | = | 60.26 | nM | 7.22 |
| CHEMBL458824 | — | IC50 | = | 87.1 | nM | 7.06 |
| CHEMBL459006 | — | IC50 | = | 93.33 | nM | 7.03 |
| CHEMBL513967 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL514761 | — | IC50 | = | 114.82 | nM | 6.94 |
| CHEMBL459007 | — | IC50 | = | 125.89 | nM | 6.90 |
| CHEMBL458826 | — | IC50 | = | 128.82 | nM | 6.89 |
| CHEMBL464390 | — | IC50 | = | 144.54 | nM | 6.84 |
| CHEMBL462788 | — | IC50 | = | 158.49 | nM | 6.80 |
| CHEMBL459174 | — | IC50 | = | 162.18 | nM | 6.79 |
| CHEMBL465216 | — | IC50 | = | 173.78 | nM | 6.76 |
| CHEMBL456651 | — | IC50 | = | 213.8 | nM | 6.67 |
| CHEMBL457741 | — | IC50 | = | 223.87 | nM | 6.65 |
| CHEMBL517910 | — | IC50 | = | 229.09 | nM | 6.64 |
| CHEMBL458101 | — | IC50 | = | 257.04 | nM | 6.59 |
| CHEMBL514126 | — | IC50 | = | 257.04 | nM | 6.59 |
| CHEMBL459181 | — | IC50 | = | 316.23 | nM | 6.50 |
| CHEMBL457740 | — | IC50 | = | 363.08 | nM | 6.44 |
| CHEMBL458353 | — | IC50 | = | 426.58 | nM | 6.37 |
| CHEMBL456241 | — | IC50 | = | 851.14 | nM | 6.07 |
| CHEMBL458981 | — | IC50 | = | 2041.74 | nM | 5.69 |
| CHEMBL515070 | — | IC50 | = | 2344.23 | nM | 5.63 |
| CHEMBL514272 | — | IC50 | = | 2754.23 | nM | 5.56 |
| CHEMBL458115 | — | IC50 | = | 3467.37 | nM | 5.46 |
| CHEMBL457708 | — | IC50 | = | 3890.45 | nM | 5.41 |
| CHEMBL458177 | — | IC50 | = | 7413.1 | nM | 5.13 |
| CHEMBL458780 | — | IC50 | = | 8317.64 | nM | 5.08 |
| CHEMBL458980 | — | IC50 | = | 8709.64 | nM | 5.06 |
| CHEMBL458169 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL514717 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL458598 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL488592 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL457707 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL515055 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL457522 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL457503 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL458839 | — | IC50 | > | 10000.0 | nM | - |