Assay Detail
Binding
CHEMBL949941
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Inhibition of human prolyl endopeptidase
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Trypanosoma cruzi |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Inhibitors of proteases and amide hydrolases that employ an alpha-ketoheterocycle as a key enabling functionality.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 7.94 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL318284 | — | — | 1 | 8.40 |
| CHEMBL273161 | — | — | 1 | 8.22 |
| CHEMBL97152 | — | — | 1 | 7.82 |
| CHEMBL269822 | — | — | 1 | 7.80 |
| CHEMBL99237 | — | — | 1 | 7.44 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL318284 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL273161 | — | Ki | = | 6.0 | nM | 8.22 |
| CHEMBL97152 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL269822 | — | Ki | = | 16.0 | nM | 7.80 |
| CHEMBL99237 | — | Ki | = | 36.0 | nM | 7.44 |