Assay Detail
Binding
CHEMBL949945
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant cathepsin K
20
Total Activities
20
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Inhibitors of proteases and amide hydrolases that employ an alpha-ketoheterocycle as a key enabling functionality.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 14 | 7.47 | 9.02 |
| IC50 | 6 | 6.06 | 8.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL209293 | — | — | 1 | 9.02 |
| CHEMBL209215 | — | — | 1 | 8.77 |
| CHEMBL116402 | — | — | 1 | 8.57 |
| CHEMBL379622 | — | — | 1 | 8.48 |
| CHEMBL405602 | — | — | 1 | 8.10 |
| CHEMBL257692 | — | — | 1 | 8.07 |
| CHEMBL270792 | — | — | 1 | 8.02 |
| CHEMBL210198 | — | — | 1 | 7.66 |
| CHEMBL211050 | — | — | 1 | 7.54 |
| CHEMBL446718 | — | — | 1 | 7.40 |
| CHEMBL208566 | — | — | 1 | 7.27 |
| CHEMBL361816 | — | — | 1 | 6.64 |
| CHEMBL272374 | — | — | 1 | 6.30 |
| CHEMBL411498 | — | — | 1 | 5.52 |
| CHEMBL361975 | — | — | 1 | 5.51 |
| CHEMBL360745 | — | — | 1 | 5.40 |
| CHEMBL181105 | — | — | 1 | 5.15 |
| CHEMBL360237 | — | — | 1 | 5.09 |
| CHEMBL272375 | — | — | 1 | 5.02 |
| CHEMBL271004 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL209293 | — | Ki | = | 0.95 | nM | 9.02 |
| CHEMBL209215 | — | Ki | = | 1.7 | nM | 8.77 |
| CHEMBL116402 | — | IC50 | = | 2.7 | nM | 8.57 |
| CHEMBL379622 | — | Ki | = | 3.3 | nM | 8.48 |
| CHEMBL405602 | — | Ki | = | 7.9 | nM | 8.10 |
| CHEMBL257692 | — | Ki | = | 8.5 | nM | 8.07 |
| CHEMBL270792 | — | Ki | = | 9.5 | nM | 8.02 |
| CHEMBL210198 | — | Ki | = | 22.0 | nM | 7.66 |
| CHEMBL211050 | — | Ki | = | 29.0 | nM | 7.54 |
| CHEMBL446718 | — | Ki | = | 40.0 | nM | 7.40 |
| CHEMBL208566 | — | Ki | = | 54.0 | nM | 7.27 |
| CHEMBL361816 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL272374 | — | Ki | = | 500.0 | nM | 6.30 |
| CHEMBL411498 | — | Ki | = | 3000.0 | nM | 5.52 |
| CHEMBL361975 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL360745 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL181105 | — | IC50 | = | 7100.0 | nM | 5.15 |
| CHEMBL360237 | — | IC50 | = | 8100.0 | nM | 5.09 |
| CHEMBL272375 | — | Ki | = | 9600.0 | nM | 5.02 |
| CHEMBL271004 | — | Ki | < | 0.25 | nM | - |