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Assay Detail

CHEMBL949947

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Binding
Inhibition of human recombinant cathepsin L
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Procathepsin L (CHEMBL3837)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Inhibitors of proteases and amide hydrolases that employ an alpha-ketoheterocycle as a key enabling functionality.
Maryanoff BE, Costanzo MJ.
Bioorg Med Chem (2008) 16 : 1562 -1595
PubMed 18053726 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 13 6.00 9.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL271004 1 9.00
CHEMBL270792 1 7.52
CHEMBL257692 1 7.16
CHEMBL379622 1 6.80
CHEMBL446718 1 6.66
CHEMBL405602 1 6.52
CHEMBL209215 1 6.00
CHEMBL208566 1 5.85
CHEMBL272374 1 4.85
CHEMBL211050 1 4.72
CHEMBL411498 1 4.55
CHEMBL210198 1 4.43
CHEMBL272375 1 4.00

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL271004 Ki = 1.0 nM 9.00
CHEMBL270792 Ki = 30.0 nM 7.52
CHEMBL257692 Ki = 70.0 nM 7.16
CHEMBL379622 Ki = 160.0 nM 6.80
CHEMBL446718 Ki = 220.0 nM 6.66
CHEMBL405602 Ki = 300.0 nM 6.52
CHEMBL209215 Ki = 1000.0 nM 6.00
CHEMBL208566 Ki = 1400.0 nM 5.85
CHEMBL272374 Ki = 14000.0 nM 4.85
CHEMBL211050 Ki = 19000.0 nM 4.72
CHEMBL411498 Ki = 28000.0 nM 4.55
CHEMBL210198 Ki = 37000.0 nM 4.43
CHEMBL272375 Ki = 100000.0 nM 4.00