Assay Detail
Binding
CHEMBL949948
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant cathepsin S
18
Total Activities
18
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Inhibitors of proteases and amide hydrolases that employ an alpha-ketoheterocycle as a key enabling functionality.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 17 | 5.95 | 7.52 |
| IC50 | 1 | 8.18 | 8.18 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL256191 | — | — | 1 | 8.18 |
| CHEMBL257692 | — | — | 1 | 7.52 |
| CHEMBL446718 | — | — | 1 | 7.40 |
| CHEMBL379622 | — | — | 1 | 6.50 |
| CHEMBL209215 | — | — | 1 | 6.46 |
| CHEMBL272374 | — | — | 1 | 6.42 |
| CHEMBL405602 | — | — | 1 | 6.33 |
| CHEMBL411498 | — | — | 1 | 5.70 |
| CHEMBL208566 | — | — | 1 | 5.48 |
| CHEMBL210198 | — | — | 1 | 4.70 |
| CHEMBL272375 | — | — | 1 | 4.58 |
| CHEMBL211050 | — | — | 1 | 4.35 |
| CHEMBL262621 | — | — | 1 | - |
| CHEMBL271004 | — | — | 1 | - |
| CHEMBL255982 | — | — | 1 | - |
| CHEMBL403019 | — | — | 1 | - |
| CHEMBL401781 | — | — | 1 | - |
| CHEMBL260818 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL256191 | — | IC50 | = | 6.6 | nM | 8.18 |
| CHEMBL257692 | — | Ki | = | 30.0 | nM | 7.52 |
| CHEMBL446718 | — | Ki | = | 40.0 | nM | 7.40 |
| CHEMBL379622 | — | Ki | = | 320.0 | nM | 6.50 |
| CHEMBL209215 | — | Ki | = | 350.0 | nM | 6.46 |
| CHEMBL272374 | — | Ki | = | 380.0 | nM | 6.42 |
| CHEMBL405602 | — | Ki | = | 470.0 | nM | 6.33 |
| CHEMBL411498 | — | Ki | = | 2000.0 | nM | 5.70 |
| CHEMBL208566 | — | Ki | = | 3300.0 | nM | 5.48 |
| CHEMBL210198 | — | Ki | = | 20000.0 | nM | 4.70 |
| CHEMBL272375 | — | Ki | = | 26000.0 | nM | 4.58 |
| CHEMBL211050 | — | Ki | = | 45000.0 | nM | 4.35 |
| CHEMBL262621 | — | Ki | < | 100.0 | nM | - |
| CHEMBL271004 | — | Ki | < | 0.25 | nM | - |
| CHEMBL255982 | — | Ki | < | 10.0 | nM | - |
| CHEMBL403019 | — | Ki | < | 100.0 | nM | - |
| CHEMBL401781 | — | Ki | < | 100.0 | nM | - |
| CHEMBL260818 | — | Ki | < | 100.0 | nM | - |