Assay Detail
Functional
CHEMBL950151
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against HIV1 RF in CEM-SS cells assessed as inhibition of virus-induced cytopathic effect by XTT assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | CEM-SS |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Investigation of the alkenyldiarylmethane non-nucleoside reverse transcriptase inhibitors as potential cAMP phosphodiesterase-4B2 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 8 | 6.65 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL107200 | — | — | 1 | 9.00 |
| CHEMBL57 | NEVIRAPINE | 4.0 | 1 | 8.82 |
| CHEMBL226735 | — | — | 1 | 7.52 |
| CHEMBL256906 | — | — | 1 | 6.21 |
| CHEMBL130984 | — | — | 1 | 5.28 |
| CHEMBL110175 | — | — | 1 | 4.89 |
| CHEMBL110359 | — | — | 1 | 4.80 |
| CHEMBL63 | ROLIPRAM | 2.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL107200 | — | EC50 | = | 1.0 | nM | 9.00 |
| CHEMBL57 | NEVIRAPINE | EC50 | = | 1.5 | nM | 8.82 |
| CHEMBL226735 | — | EC50 | = | 30.0 | nM | 7.52 |
| CHEMBL256906 | — | EC50 | = | 620.0 | nM | 6.21 |
| CHEMBL130984 | — | EC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL110175 | — | EC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL110359 | — | EC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL63 | ROLIPRAM | EC50 | - | — | - |