Assay Detail
Functional
CHEMBL950152
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against HIV1 3B in MT4 cells assessed as inhibition of virus-induced cytopathic effect by MTT assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | MT4 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Investigation of the alkenyldiarylmethane non-nucleoside reverse transcriptase inhibitors as potential cAMP phosphodiesterase-4B2 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 8 | 6.62 | 7.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL57 | NEVIRAPINE | 4.0 | 1 | 7.28 |
| CHEMBL226735 | — | — | 1 | 7.05 |
| CHEMBL256906 | — | — | 1 | 6.66 |
| CHEMBL107200 | — | — | 1 | 6.52 |
| CHEMBL110175 | — | — | 1 | 5.58 |
| CHEMBL63 | ROLIPRAM | 2.0 | 1 | - |
| CHEMBL130984 | — | — | 1 | - |
| CHEMBL110359 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL57 | NEVIRAPINE | EC50 | = | 53.0 | nM | 7.28 |
| CHEMBL226735 | — | EC50 | = | 90.0 | nM | 7.05 |
| CHEMBL256906 | — | EC50 | = | 220.0 | nM | 6.66 |
| CHEMBL107200 | — | EC50 | = | 300.0 | nM | 6.52 |
| CHEMBL110175 | — | EC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL63 | ROLIPRAM | EC50 | - | — | - | |
| CHEMBL130984 | — | EC50 | - | — | - | |
| CHEMBL110359 | — | EC50 | - | — | - |