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Assay Detail

CHEMBL950158

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Displacement of [125I]TZDM from beta amyloid protein 42
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

Synthesis and evaluation of stilbenylbenzoxazole and stilbenylbenzothiazole derivatives for detecting beta-amyloid fibrils.
Lee JH, Byeon SR, Lim SJ, Oh SJ, Moon DH, Yoo KH, Chung BY, Kim DJ.
Bioorg Med Chem Lett (2008) 18 : 1534 -1537
PubMed 18226893 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 25 9.36 10.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL255852 1 10.00
CHEMBL270152 1 9.92
CHEMBL255978 1 9.49
CHEMBL258305 1 9.46
CHEMBL256178 1 9.42
CHEMBL255851 1 9.39
CHEMBL430032 1 9.38
CHEMBL402141 1 9.36
CHEMBL277727 1 9.35
CHEMBL429322 1 9.35
CHEMBL258268 1 9.35
CHEMBL272322 1 9.34
CHEMBL401515 1 9.33
CHEMBL258082 1 9.33
CHEMBL270369 1 9.32
CHEMBL256179 1 9.31
CHEMBL257734 1 9.30
CHEMBL270427 1 9.28
CHEMBL429672 1 9.26
CHEMBL270428 1 9.24
CHEMBL258337 1 9.23
CHEMBL270429 1 9.23
CHEMBL272532 1 9.17
CHEMBL415282 1 9.13
CHEMBL207456 PITTSBURGH COMPOUND B 2.0 1 9.11

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL255852 Ki = 0.1 nM 10.00
CHEMBL270152 Ki = 0.12 nM 9.92
CHEMBL255978 Ki = 0.32 nM 9.49
CHEMBL258305 Ki = 0.35 nM 9.46
CHEMBL256178 Ki = 0.38 nM 9.42
CHEMBL255851 Ki = 0.41 nM 9.39
CHEMBL430032 Ki = 0.42 nM 9.38
CHEMBL402141 Ki = 0.44 nM 9.36
CHEMBL277727 Ki = 0.45 nM 9.35
CHEMBL429322 Ki = 0.45 nM 9.35
CHEMBL258268 Ki = 0.45 nM 9.35
CHEMBL272322 Ki = 0.46 nM 9.34
CHEMBL401515 Ki = 0.47 nM 9.33
CHEMBL258082 Ki = 0.47 nM 9.33
CHEMBL270369 Ki = 0.48 nM 9.32
CHEMBL256179 Ki = 0.49 nM 9.31
CHEMBL257734 Ki = 0.5 nM 9.30
CHEMBL270427 Ki = 0.52 nM 9.28
CHEMBL429672 Ki = 0.55 nM 9.26
CHEMBL270428 Ki = 0.57 nM 9.24
CHEMBL258337 Ki = 0.59 nM 9.23
CHEMBL270429 Ki = 0.59 nM 9.23
CHEMBL272532 Ki = 0.68 nM 9.17
CHEMBL415282 Ki = 0.74 nM 9.13
CHEMBL207456 PITTSBURGH COMPOUND B Ki = 0.77 nM 9.11