Assay Detail
Binding
CHEMBL950217
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Inhibition of CSF1R
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Macrophage colony-stimulating factor 1 receptor (CHEMBL1844) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Design and synthesis of a pyrido[2,3-d]pyrimidin-5-one class of anti-inflammatory FMS inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.50 | 7.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL414001 | — | — | 1 | 7.89 |
| CHEMBL256893 | — | — | 1 | 7.85 |
| CHEMBL258365 | PTERIDINONE | — | 1 | 6.75 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL414001 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL256893 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL258365 | PTERIDINONE | IC50 | = | 180.0 | nM | 6.75 |