Assay Detail
Functional
CHEMBL950322
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Agonist activity at mu opioid receptor in Hartley guinea pig assessed as inhibition of electrically evoked-contraction
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis of a potent and selective (18)F-labeled delta-opioid receptor antagonist derived from the Dmt-Tic pharmacophore for positron emission tomography imaging.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.51 | 7.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL269842 | — | — | 1 | 7.30 |
| CHEMBL244265 | — | — | 1 | 5.72 |
| CHEMBL270984 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL269842 | — | IC50 | = | 50.6 | nM | 7.30 |
| CHEMBL244265 | — | IC50 | = | 1916.0 | nM | 5.72 |
| CHEMBL270984 | — | IC50 | > | 10000.0 | nM | - |