Assay Detail
Binding
CHEMBL950410
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Displacement of [3H]flumazenil from GABAA in rat cortical tissue
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Azaflavones compared to flavones as ligands to the benzodiazepine binding site of brain GABA(A) receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 11 | 7.19 | 9.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL522061 | — | — | 1 | 9.22 |
| CHEMBL335086 | — | — | 1 | 9.05 |
| CHEMBL502159 | — | — | 1 | 8.70 |
| CHEMBL452728 | — | — | 1 | 7.66 |
| CHEMBL134732 | — | — | 1 | 6.75 |
| CHEMBL497602 | — | — | 1 | 6.40 |
| CHEMBL496582 | — | — | 1 | 6.14 |
| CHEMBL496347 | — | — | 1 | 6.08 |
| CHEMBL526464 | — | — | 1 | 5.96 |
| CHEMBL497603 | — | — | 1 | 5.92 |
| CHEMBL134315 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL522061 | — | Ki | = | 0.6 | nM | 9.22 |
| CHEMBL335086 | — | Ki | = | 0.9 | nM | 9.05 |
| CHEMBL502159 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL452728 | — | Ki | = | 22.0 | nM | 7.66 |
| CHEMBL134732 | — | Ki | = | 180.0 | nM | 6.75 |
| CHEMBL497602 | — | Ki | = | 400.0 | nM | 6.40 |
| CHEMBL496582 | — | Ki | = | 730.0 | nM | 6.14 |
| CHEMBL496347 | — | Ki | = | 840.0 | nM | 6.08 |
| CHEMBL526464 | — | Ki | = | 1100.0 | nM | 5.96 |
| CHEMBL497603 | — | Ki | = | 1200.0 | nM | 5.92 |
| CHEMBL134315 | — | Ki | > | 1500.0 | nM | - |