Compound Detail
CHEMBL335086
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Basic Information
| ChEMBL ID | CHEMBL335086 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | ALGFQPMFHIDLFQ-UHFFFAOYSA-N |
3
Targets
3
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
331.2
MW (Da)
4.24
ALogP
3
HBA
1
HBD
50.4
PSA (Ų)
0.73
QED
0
Ro5 Violations
1
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 3 meas. best 9.05
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| GABA-A receptor; anion channel CHEMBL1907607 | Ki | 9.05 | 9.05 | 0.9 | 1 |
| Benzodiazepine receptors; peripheral & central CHEMBL2096683 | Ki | 9.05 | 9.05 | 0.9 | 1 |
| Unchecked CHEMBL612545 | Ki | 9.05 | 9.05 | 0.9 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| GABA-A receptor; anion channel | Ki | = | 0.9 | nM | 9.05 | Ability to inhibit [3H]-Ro- 15-1788 binding to Gamma-aminobutyric acid A recepto... | 12213060 |
| Unchecked | Ki | = | 0.9 | nM | 9.05 | Displacement of [3H]flumazenil from GABAA in rat cortical tissue | 18851913 |
| Benzodiazepine receptors; peripheral & central | Ki | = | 0.9 | nM | 9.05 | Binding affinity to benzodiazepine receptor (unknown origin) | 25019478 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 18851913 | 10.1016/j.bmcl.2008.09.092 | Unchecked | 3 |
| 12213060 | 10.1021/jm020839k | GABA-A receptor; anion channel | 1 |
| 25019478 | 10.1016/j.ejmech.2014.07.013 | Benzodiazepine receptors; peripheral & central | 1 |
Data from ChEMBL 36 via Core Engine