Assay Detail
Functional
CHEMBL950580
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Antimalarial activity against mefloquine, chloroquine and quinine-resistant Plasmodium falciparum TM91C235
21
Total Activities
11
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Mixed tetraoxanes containing the acetone subunit as antimalarials.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC90 | 11 | - | - |
| IC50 | 10 | 7.47 | 8.14 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL450192 | — | — | 2 | 8.14 |
| CHEMBL501647 | — | — | 2 | 7.80 |
| CHEMBL416956 | MEFLOQUINE | 4.0 | 2 | 7.78 |
| CHEMBL507515 | — | — | 2 | 7.60 |
| CHEMBL505437 | — | — | 2 | 7.58 |
| CHEMBL510410 | — | — | 2 | 7.55 |
| CHEMBL509229 | — | — | 2 | 7.50 |
| CHEMBL499752 | — | — | 2 | 7.22 |
| CHEMBL76 | CHLOROQUINE | 4.0 | 2 | 6.84 |
| CHEMBL510548 | — | — | 2 | 6.64 |
| CHEMBL269671 | ARTEMISININ | 3.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL450192 | — | IC50 | = | 7.16 | nM | 8.14 |
| CHEMBL501647 | — | IC50 | = | 15.75 | nM | 7.80 |
| CHEMBL416956 | MEFLOQUINE | IC50 | = | 16.44 | nM | 7.78 |
| CHEMBL507515 | — | IC50 | = | 25.13 | nM | 7.60 |
| CHEMBL505437 | — | IC50 | = | 25.99 | nM | 7.58 |
| CHEMBL510410 | — | IC50 | = | 28.47 | nM | 7.55 |
| CHEMBL509229 | — | IC50 | = | 31.28 | nM | 7.50 |
| CHEMBL499752 | — | IC50 | = | 60.44 | nM | 7.22 |
| CHEMBL76 | CHLOROQUINE | IC50 | = | 144.9 | nM | 6.84 |
| CHEMBL510548 | — | IC50 | = | 227.7 | nM | 6.64 |
| CHEMBL505437 | — | IC90 | = | 57.27 | nM | - |
| CHEMBL76 | CHLOROQUINE | IC90 | = | 268.76 | nM | - |
| CHEMBL416956 | MEFLOQUINE | IC90 | = | 65.71 | nM | - |
| CHEMBL269671 | ARTEMISININ | IC90 | = | 13.04 | nM | - |
| CHEMBL510548 | — | IC90 | = | 498.31 | nM | - |
| CHEMBL507515 | — | IC90 | = | 50.93 | nM | - |
| CHEMBL501647 | — | IC90 | = | 20.89 | nM | - |
| CHEMBL450192 | — | IC90 | = | 19.82 | nM | - |
| CHEMBL509229 | — | IC90 | = | 74.82 | nM | - |
| CHEMBL499752 | — | IC90 | = | 231.16 | nM | - |
| CHEMBL510410 | — | IC90 | = | 38.07 | nM | - |