Assay Detail
Functional
CHEMBL950581
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Antimalarial activity against chloroquine and pyrimethamine-sensitive Plasmodium falciparum D6
28
Total Activities
14
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Mixed tetraoxanes containing the acetone subunit as antimalarials.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 7.72 | 8.16 |
| IC90 | 14 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL501647 | — | — | 2 | 8.16 |
| CHEMBL503659 | — | — | 2 | 8.13 |
| CHEMBL269671 | ARTEMISININ | 3.0 | 2 | 8.05 |
| CHEMBL416956 | MEFLOQUINE | 4.0 | 2 | 7.98 |
| CHEMBL450192 | — | — | 2 | 7.94 |
| CHEMBL510717 | — | — | 2 | 7.91 |
| CHEMBL76 | CHLOROQUINE | 4.0 | 2 | 7.86 |
| CHEMBL444498 | — | — | 2 | 7.84 |
| CHEMBL505437 | — | — | 2 | 7.82 |
| CHEMBL510410 | — | — | 2 | 7.55 |
| CHEMBL507515 | — | — | 2 | 7.45 |
| CHEMBL509229 | — | — | 2 | 7.33 |
| CHEMBL499752 | — | — | 2 | 7.33 |
| CHEMBL510548 | — | — | 2 | 6.67 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL501647 | — | IC50 | = | 6.97 | nM | 8.16 |
| CHEMBL503659 | — | IC50 | = | 7.4 | nM | 8.13 |
| CHEMBL269671 | ARTEMISININ | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL416956 | MEFLOQUINE | IC50 | = | 10.52 | nM | 7.98 |
| CHEMBL450192 | — | IC50 | = | 11.6 | nM | 7.94 |
| CHEMBL510717 | — | IC50 | = | 12.21 | nM | 7.91 |
| CHEMBL76 | CHLOROQUINE | IC50 | = | 13.72 | nM | 7.86 |
| CHEMBL444498 | — | IC50 | = | 14.28 | nM | 7.84 |
| CHEMBL505437 | — | IC50 | = | 14.98 | nM | 7.82 |
| CHEMBL510410 | — | IC50 | = | 28.1 | nM | 7.55 |
| CHEMBL507515 | — | IC50 | = | 35.54 | nM | 7.45 |
| CHEMBL509229 | — | IC50 | = | 46.87 | nM | 7.33 |
| CHEMBL499752 | — | IC50 | = | 46.5 | nM | 7.33 |
| CHEMBL510548 | — | IC50 | = | 215.25 | nM | 6.67 |
| CHEMBL505437 | — | IC90 | = | 26.68 | nM | - |
| CHEMBL76 | CHLOROQUINE | IC90 | = | 17.63 | nM | - |
| CHEMBL416956 | MEFLOQUINE | IC90 | = | 21.65 | nM | - |
| CHEMBL269671 | ARTEMISININ | IC90 | = | 12.8 | nM | - |
| CHEMBL510548 | — | IC90 | = | 346.51 | nM | - |
| CHEMBL510410 | — | IC90 | = | 46.31 | nM | - |
| CHEMBL507515 | — | IC90 | = | 71.47 | nM | - |
| CHEMBL444498 | — | IC90 | - | — | - | |
| CHEMBL501647 | — | IC90 | = | 20.84 | nM | - |
| CHEMBL499752 | — | IC90 | = | 96.28 | nM | - |
| CHEMBL450192 | — | IC90 | = | 26.24 | nM | - |
| CHEMBL510717 | — | IC90 | - | — | - | |
| CHEMBL503659 | — | IC90 | = | 16.16 | nM | - |
| CHEMBL509229 | — | IC90 | = | 78.28 | nM | - |