Assay Detail

CHEMBL950790

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Binding

Inhibition of PKCalpha

ChEMBL ↗

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Target

Protein kinase C alpha type (CHEMBL299) ↗

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Primary target Protein kinase C alpha type

CHEMBL299

Anchored from Assay target.

Protein identity Protein kinase C alpha type

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Confidence	8 — Homologous single protein target
Curated By	Intermediate

Target

Protein kinase C alpha type (CHEMBL299) ↗

Type	SINGLE PROTEIN
Organism	Homo sapiens

Publication

Minocycline down-regulates MHC II expression in microglia and macrophages through inhibition of IRF-1 and protein kinase C (PKC)alpha/betaII.

Nikodemova M, Watters JJ, Jackson SJ, Yang SK, Duncan ID.
J Biol Chem (2007) 282 : 15208 -15216
PubMed 17395590 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	1	8.64	8.64

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL302449	GO-6976	—	1	8.64

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL302449	GO-6976	IC50	=	2.3	nM	8.64