Assay Detail
Functional
CHEMBL950877
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at FXR expressed in african green monkey CV1 cells coexpressed with human SHP by reporter gene assay
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Cell Type | CV-1 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
Discovery of XL335 (WAY-362450), a highly potent, selective, and orally active agonist of the farnesoid X receptor (FXR).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 1 | 6.64 | 6.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL454138 | TUROFEXORATE ISOPROPYL | 2.0 | 1 | 6.64 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL454138 | TUROFEXORATE ISOPROPYL | EC50 | = | 230.0 | nM | 6.64 |