Assay Detail
Binding
CHEMBL951044
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]ketanserin from 5HT2 receptor in pig cortical membranes
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Sus scrofa |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis, radiofluorination, and in vitro evaluation of pyrazolo[1,5-a]pyridine-based dopamine D4 receptor ligands: discovery of an inverse agonist radioligand for PET.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 12 | 5.42 | 6.42 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL7927 | FAUC 113 | — | 1 | 6.42 |
| CHEMBL310843 | — | — | 1 | 6.05 |
| CHEMBL272395 | — | — | 1 | 5.92 |
| CHEMBL272602 | — | — | 1 | 5.82 |
| CHEMBL411437 | — | — | 1 | 5.54 |
| CHEMBL272396 | — | — | 1 | 5.36 |
| CHEMBL270056 | — | — | 1 | 5.27 |
| CHEMBL272853 | — | — | 1 | 5.26 |
| CHEMBL405292 | — | — | 1 | 5.01 |
| CHEMBL405260 | — | — | 1 | 4.89 |
| CHEMBL272873 | — | — | 1 | 4.85 |
| CHEMBL407818 | — | — | 1 | 4.61 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL7927 | FAUC 113 | Ki | = | 380.0 | nM | 6.42 |
| CHEMBL310843 | — | Ki | = | 900.0 | nM | 6.05 |
| CHEMBL272395 | — | Ki | = | 1200.0 | nM | 5.92 |
| CHEMBL272602 | — | Ki | = | 1500.0 | nM | 5.82 |
| CHEMBL411437 | — | Ki | = | 2900.0 | nM | 5.54 |
| CHEMBL272396 | — | Ki | = | 4400.0 | nM | 5.36 |
| CHEMBL270056 | — | Ki | = | 5400.0 | nM | 5.27 |
| CHEMBL272853 | — | Ki | = | 5500.0 | nM | 5.26 |
| CHEMBL405292 | — | Ki | = | 9700.0 | nM | 5.01 |
| CHEMBL405260 | — | Ki | = | 13000.0 | nM | 4.89 |
| CHEMBL272873 | — | Ki | = | 14000.0 | nM | 4.85 |
| CHEMBL407818 | — | Ki | = | 24700.0 | nM | 4.61 |