Assay Detail
Binding
CHEMBL951085
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Inhibition of human recombinant Akt1
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
RAC-alpha serine/threonine-protein kinase (CHEMBL4282) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Rapid assembly of diverse and potent allosteric Akt inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 6.74 | 7.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL253458 | — | — | 1 | 7.85 |
| CHEMBL253457 | — | — | 1 | 7.75 |
| CHEMBL255348 | — | — | 1 | 7.68 |
| CHEMBL255835 | — | — | 1 | 7.68 |
| CHEMBL258844 | — | — | 1 | 7.24 |
| CHEMBL402579 | — | — | 1 | 7.16 |
| CHEMBL402199 | — | — | 1 | 7.09 |
| CHEMBL270157 | — | — | 1 | 7.07 |
| CHEMBL401999 | — | — | 1 | 6.97 |
| CHEMBL401622 | — | — | 1 | 6.92 |
| CHEMBL255360 | — | — | 1 | 6.89 |
| CHEMBL255559 | — | — | 1 | 6.88 |
| CHEMBL270815 | — | — | 1 | 6.61 |
| CHEMBL270388 | — | — | 1 | 6.60 |
| CHEMBL429576 | — | — | 1 | 6.30 |
| CHEMBL255772 | — | — | 1 | 5.65 |
| CHEMBL362455 | — | — | 1 | 5.47 |
| CHEMBL402355 | — | — | 1 | 5.26 |
| CHEMBL257441 | — | — | 1 | 5.07 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL253458 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL253457 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL255348 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL255835 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL258844 | — | IC50 | = | 58.0 | nM | 7.24 |
| CHEMBL402579 | — | IC50 | = | 69.0 | nM | 7.16 |
| CHEMBL402199 | — | IC50 | = | 81.0 | nM | 7.09 |
| CHEMBL270157 | — | IC50 | = | 86.0 | nM | 7.07 |
| CHEMBL401999 | — | IC50 | = | 107.0 | nM | 6.97 |
| CHEMBL401622 | — | IC50 | = | 121.0 | nM | 6.92 |
| CHEMBL255360 | — | IC50 | = | 129.0 | nM | 6.89 |
| CHEMBL255559 | — | IC50 | = | 131.0 | nM | 6.88 |
| CHEMBL270815 | — | IC50 | = | 244.0 | nM | 6.61 |
| CHEMBL270388 | — | IC50 | = | 253.0 | nM | 6.60 |
| CHEMBL429576 | — | IC50 | = | 495.0 | nM | 6.30 |
| CHEMBL255772 | — | IC50 | = | 2249.0 | nM | 5.65 |
| CHEMBL362455 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL402355 | — | IC50 | = | 5548.0 | nM | 5.26 |
| CHEMBL257441 | — | IC50 | = | 8457.0 | nM | 5.07 |