Assay Detail
Binding
CHEMBL951088
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Akt1 phosphorylation in human C33a cells
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | C33a |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
RAC-alpha serine/threonine-protein kinase (CHEMBL4282) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Rapid assembly of diverse and potent allosteric Akt inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.36 | 6.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL402579 | — | — | 1 | 6.66 |
| CHEMBL253457 | — | — | 1 | 6.56 |
| CHEMBL253458 | — | — | 1 | 6.53 |
| CHEMBL255835 | — | — | 1 | 6.33 |
| CHEMBL402199 | — | — | 1 | 5.74 |
| CHEMBL255360 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL402579 | — | IC50 | = | 221.0 | nM | 6.66 |
| CHEMBL253457 | — | IC50 | = | 277.0 | nM | 6.56 |
| CHEMBL253458 | — | IC50 | = | 295.0 | nM | 6.53 |
| CHEMBL255835 | — | IC50 | = | 463.0 | nM | 6.33 |
| CHEMBL402199 | — | IC50 | = | 1834.0 | nM | 5.74 |
| CHEMBL255360 | — | IC50 | - | — | - |