Assay Detail
Functional
CHEMBL951105
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Inhibition of anti-CD3-induced IL2 production in human whole blood by ELISA
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Tissue | Blood |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Structure-guided design of aminopyrimidine amides as potent, selective inhibitors of lymphocyte specific kinase: synthesis, structure-activity relationships, and inhibition of in vivo T cell activation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 7.64 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL271140 | — | — | 1 | 8.70 |
| CHEMBL272888 | — | — | 1 | 8.15 |
| CHEMBL271141 | — | — | 1 | 7.89 |
| CHEMBL407063 | — | — | 1 | 7.80 |
| CHEMBL272850 | — | — | 1 | 7.37 |
| CHEMBL411632 | — | — | 1 | 5.90 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL271140 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL272888 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL271141 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL407063 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL272850 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL411632 | — | IC50 | = | 1270.0 | nM | 5.90 |