Assay Detail
Binding
CHEMBL951281
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Inhibition of Tie2
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Evaluation of a series of naphthamides as potent, orally active vascular endothelial growth factor receptor-2 tyrosine kinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 24 | 5.06 | 6.24 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL429743 | — | — | 1 | 6.24 |
| CHEMBL428961 | — | — | 1 | 5.96 |
| CHEMBL410903 | — | — | 1 | 5.85 |
| CHEMBL272250 | — | — | 1 | 5.75 |
| CHEMBL259252 | — | — | 1 | 5.40 |
| CHEMBL409103 | — | — | 1 | 5.37 |
| CHEMBL260532 | — | — | 1 | 5.28 |
| CHEMBL411284 | — | — | 1 | 5.13 |
| CHEMBL260531 | — | — | 1 | 5.08 |
| CHEMBL271189 | — | — | 1 | 5.08 |
| CHEMBL270342 | — | — | 1 | 5.08 |
| CHEMBL412278 | — | — | 1 | 5.08 |
| CHEMBL270556 | — | — | 1 | 5.08 |
| CHEMBL270755 | — | — | 1 | 5.03 |
| CHEMBL270754 | — | — | 1 | 4.60 |
| CHEMBL269871 | — | — | 1 | 4.60 |
| CHEMBL272198 | — | — | 1 | 4.60 |
| CHEMBL408211 | — | — | 1 | 4.60 |
| CHEMBL406914 | — | — | 1 | 4.60 |
| CHEMBL410840 | — | — | 1 | 4.60 |
| CHEMBL271188 | — | — | 1 | 4.60 |
| CHEMBL271984 | — | — | 1 | 4.60 |
| CHEMBL272251 | — | — | 1 | 4.60 |
| CHEMBL272252 | — | — | 1 | 4.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL429743 | — | IC50 | = | 580.0 | nM | 6.24 |
| CHEMBL428961 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL410903 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL272250 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL259252 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL409103 | — | IC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL260532 | — | IC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL411284 | — | IC50 | = | 7400.0 | nM | 5.13 |
| CHEMBL260531 | — | IC50 | = | 8300.0 | nM | 5.08 |
| CHEMBL271189 | — | IC50 | = | 8300.0 | nM | 5.08 |
| CHEMBL270342 | — | IC50 | = | 8300.0 | nM | 5.08 |
| CHEMBL412278 | — | IC50 | = | 8300.0 | nM | 5.08 |
| CHEMBL270556 | — | IC50 | = | 8300.0 | nM | 5.08 |
| CHEMBL270755 | — | IC50 | = | 9400.0 | nM | 5.03 |
| CHEMBL270754 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL269871 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL272198 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL408211 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL406914 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL410840 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL271188 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL271984 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL272251 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL272252 | — | IC50 | = | 25000.0 | nM | 4.60 |