Assay Detail
Binding
CHEMBL951285
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Inhibition of Aurora B
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Evaluation of a series of naphthamides as potent, orally active vascular endothelial growth factor receptor-2 tyrosine kinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 24 | 6.94 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL270755 | — | — | 1 | 8.00 |
| CHEMBL410840 | — | — | 1 | 7.80 |
| CHEMBL429743 | — | — | 1 | 7.75 |
| CHEMBL269871 | — | — | 1 | 7.34 |
| CHEMBL428961 | — | — | 1 | 7.21 |
| CHEMBL270754 | — | — | 1 | 6.96 |
| CHEMBL272198 | — | — | 1 | 6.93 |
| CHEMBL271188 | — | — | 1 | 6.89 |
| CHEMBL272252 | — | — | 1 | 6.89 |
| CHEMBL272250 | — | — | 1 | 6.73 |
| CHEMBL408211 | — | — | 1 | 6.72 |
| CHEMBL271984 | — | — | 1 | 6.66 |
| CHEMBL260531 | — | — | 1 | 6.63 |
| CHEMBL411284 | — | — | 1 | 6.44 |
| CHEMBL412278 | — | — | 1 | 6.42 |
| CHEMBL260532 | — | — | 1 | 6.41 |
| CHEMBL270556 | — | — | 1 | 6.17 |
| CHEMBL271189 | — | — | 1 | - |
| CHEMBL270342 | — | — | 1 | - |
| CHEMBL406914 | — | — | 1 | - |
| CHEMBL409103 | — | — | 1 | - |
| CHEMBL272251 | — | — | 1 | - |
| CHEMBL410903 | — | — | 1 | - |
| CHEMBL259252 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL270755 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL410840 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL429743 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL269871 | — | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL428961 | — | IC50 | = | 62.0 | nM | 7.21 |
| CHEMBL270754 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL272198 | — | IC50 | = | 118.0 | nM | 6.93 |
| CHEMBL271188 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL272252 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL272250 | — | IC50 | = | 185.0 | nM | 6.73 |
| CHEMBL408211 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL271984 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL260531 | — | IC50 | = | 233.0 | nM | 6.63 |
| CHEMBL411284 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL412278 | — | IC50 | = | 385.0 | nM | 6.42 |
| CHEMBL260532 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL270556 | — | IC50 | = | 680.0 | nM | 6.17 |
| CHEMBL271189 | — | IC50 | - | — | - | |
| CHEMBL270342 | — | IC50 | - | — | - | |
| CHEMBL406914 | — | IC50 | - | — | - | |
| CHEMBL409103 | — | IC50 | - | — | - | |
| CHEMBL272251 | — | IC50 | - | — | - | |
| CHEMBL410903 | — | IC50 | - | — | - | |
| CHEMBL259252 | — | IC50 | - | — | - |