Assay Detail
Functional
CHEMBL951297
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Ex vivo antiangiogenic activity in rat aortic ring explant assessed as inhibition of microvessel growth after 8 days
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Tissue | Aorta |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
TIE-2/VEGF-R2 SAR and in vitro activity of C3-acyl dihydroindazolo[5,4-a]pyrrolo[3,4-c]carbazole analogs.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 2 | 7.70 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL444105 | — | — | 1 | 7.70 |
| CHEMBL269924 | — | — | 1 | 7.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL444105 | — | EC50 | = | 20.0 | nM | 7.70 |
| CHEMBL269924 | — | EC50 | = | 20.0 | nM | 7.70 |