Assay Detail
Binding
CHEMBL951579
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Akt1 phosphorylation in human by C33a cells by IPKA assay
28
Total Activities
28
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | C33a |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Target
RAC-alpha serine/threonine-protein kinase (CHEMBL4282) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of potent and cell-active allosteric dual Akt 1 and 2 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 25 | 7.45 | 8.52 |
| Activity | 3 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL447168 | — | — | 1 | 8.52 |
| CHEMBL448991 | — | — | 1 | 8.22 |
| CHEMBL443661 | — | — | 1 | 8.00 |
| CHEMBL447348 | — | — | 1 | 7.89 |
| CHEMBL453586 | — | — | 1 | 7.82 |
| CHEMBL500993 | — | — | 1 | 7.77 |
| CHEMBL453995 | — | — | 1 | 7.77 |
| CHEMBL488654 | — | — | 1 | 7.72 |
| CHEMBL252857 | — | — | 1 | 7.70 |
| CHEMBL502426 | — | — | 1 | 7.70 |
| CHEMBL454859 | — | — | 1 | 7.64 |
| CHEMBL448926 | — | — | 1 | 7.46 |
| CHEMBL503980 | — | — | 1 | 7.44 |
| CHEMBL504251 | — | — | 1 | 7.44 |
| CHEMBL442718 | — | — | 1 | 7.44 |
| CHEMBL448826 | — | — | 1 | 7.38 |
| CHEMBL450545 | — | — | 1 | 7.34 |
| CHEMBL499683 | — | — | 1 | 7.21 |
| CHEMBL451961 | — | — | 1 | 7.12 |
| CHEMBL508754 | — | — | 1 | 7.12 |
| CHEMBL252456 | — | — | 1 | 7.11 |
| CHEMBL447044 | — | — | 1 | 6.90 |
| CHEMBL454210 | — | — | 1 | 6.71 |
| CHEMBL505758 | — | — | 1 | 6.68 |
| CHEMBL448196 | — | — | 1 | 6.03 |
| CHEMBL450772 | — | — | 1 | - |
| CHEMBL506434 | — | — | 1 | - |
| CHEMBL443633 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL447168 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL448991 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL443661 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL447348 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL453586 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL500993 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL453995 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL488654 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL252857 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL502426 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL454859 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL448926 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL503980 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL504251 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL442718 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL448826 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL450545 | — | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL499683 | — | IC50 | = | 61.0 | nM | 7.21 |
| CHEMBL451961 | — | IC50 | = | 75.0 | nM | 7.12 |
| CHEMBL508754 | — | IC50 | = | 75.0 | nM | 7.12 |
| CHEMBL252456 | — | IC50 | = | 78.0 | nM | 7.11 |
| CHEMBL447044 | — | IC50 | = | 125.0 | nM | 6.90 |
| CHEMBL454210 | — | IC50 | = | 194.0 | nM | 6.71 |
| CHEMBL505758 | — | IC50 | = | 208.0 | nM | 6.68 |
| CHEMBL448196 | — | IC50 | = | 924.0 | nM | 6.03 |
| CHEMBL450772 | — | Activity | - | — | - | |
| CHEMBL506434 | — | Activity | - | — | - | |
| CHEMBL443633 | — | Activity | - | — | - |